ID   VASW_VIBCH              Reviewed;         295 AA.
AC   Q9KNE6;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Accessory protein VasW {ECO:0000303|PubMed:24348240};
GN   Name=vasW {ECO:0000303|PubMed:24348240}; OrderedLocusNames=VC_A0019;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24348240; DOI=10.1371/journal.ppat.1003752;
RA   Miyata S.T., Unterweger D., Rudko S.P., Pukatzki S.;
RT   "Dual expression profile of type VI secretion system immunity genes
RT   protects pandemic Vibrio cholerae.";
RL   PLoS Pathog. 9:E1003752-E1003752(2013).
CC   -!- FUNCTION: Plays an accessory role in VasX-mediated bacterial killing.
CC       {ECO:0000269|PubMed:24348240}.
CC   -!- DISRUPTION PHENOTYPE: Deletion results in an attenuated phenotype
CC       towards V. parahaemolyticus. {ECO:0000269|PubMed:24348240}.
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DR   EMBL; AE003853; AAF95933.1; -; Genomic_DNA.
DR   PIR; G82511; G82511.
DR   RefSeq; NP_232420.1; NC_002506.1.
DR   RefSeq; WP_001257973.1; NZ_LT906615.1.
DR   AlphaFoldDB; Q9KNE6; -.
DR   STRING; 243277.VC_A0019; -.
DR   TCDB; 1.C.131.1.1; the vasx toxin (vasx) family.
DR   PRIDE; Q9KNE6; -.
DR   DNASU; 2612521; -.
DR   EnsemblBacteria; AAF95933; AAF95933; VC_A0019.
DR   GeneID; 57741494; -.
DR   KEGG; vch:VC_A0019; -.
DR   PATRIC; fig|243277.26.peg.2666; -.
DR   eggNOG; COG4104; Bacteria.
DR   HOGENOM; CLU_082103_0_0_6; -.
DR   OMA; IAQWFES; -.
DR   BioCyc; VCHO:VCA0019-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   InterPro; IPR025391; DUF4123.
DR   Pfam; PF13503; DUF4123; 1.
PE   4: Predicted;
KW   Reference proteome; Virulence.
FT   CHAIN           1..295
FT                   /note="Accessory protein VasW"
FT                   /id="PRO_0000449210"
SQ   SEQUENCE   295 AA;  34214 MW;  0C2247A08F4B8068 CRC64;
     MRSTNSFVVH NWVSLVPEME MDTQERLYLL VDGAQISHLA QALYRLSGEL VLEPLYLFPP
     FEQLKEVSPY LVLATDTVKT WFLEQNQGLA GFFFASLDSI EEIAEQLRRL IQVESPYGST
     VFLKMANSEC AYVLLSTQCQ PLWKVINRAW LPTRQGWQYV QRPELTATQD TPVRFKLTDE
     QWQRLGNITW LNTLETVERH VQQWFPDLAQ QWQSDPELFH RHAQWAYQQG FSSERDLMLF
     FNVLGFLGVD ALEKGKYPEI DPLLHQASSR TPSQRIEAAA ELAYQHSQSS QEVQG