CAHD1_DROME
ID CAHD1_DROME Reviewed; 1449 AA.
AC Q5BI42;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=VWFA and cache domain-containing protein CG16868;
DE Flags: Precursor;
GN ORFNames=CG16868;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57485.1; -; Genomic_DNA.
DR EMBL; BT021382; AAX33530.1; -; mRNA.
DR RefSeq; NP_611469.1; NM_137625.2.
DR AlphaFoldDB; Q5BI42; -.
DR IntAct; Q5BI42; 1.
DR STRING; 7227.FBpp0085614; -.
DR GlyGen; Q5BI42; 13 sites.
DR PaxDb; Q5BI42; -.
DR PRIDE; Q5BI42; -.
DR DNASU; 37298; -.
DR EnsemblMetazoa; FBtr0086302; FBpp0085614; FBgn0034498.
DR GeneID; 37298; -.
DR KEGG; dme:Dmel_CG16868; -.
DR UCSC; CG16868-RA; d. melanogaster.
DR FlyBase; FBgn0034498; CG16868.
DR VEuPathDB; VectorBase:FBgn0034498; -.
DR eggNOG; KOG2353; Eukaryota.
DR GeneTree; ENSGT00940000157568; -.
DR HOGENOM; CLU_004521_0_0_1; -.
DR InParanoid; Q5BI42; -.
DR OMA; KSFVHEM; -.
DR OrthoDB; 260352at2759; -.
DR PhylomeDB; Q5BI42; -.
DR BioGRID-ORCS; 37298; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37298; -.
DR PRO; PR:Q5BI42; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034498; Expressed in cleaving embryo and 21 other tissues.
DR Genevisible; Q5BI42; DM.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR SUPFAM; SSF103190; SSF103190; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Calcium; Calcium transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1449
FT /note="VWFA and cache domain-containing protein CG16868"
FT /id="PRO_0000304663"
FT TOPO_DOM 24..1220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1221..1241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1242..1449
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 320..541
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 557..639
FT /note="Cache 1"
FT DOMAIN 889..934
FT /note="Cache 2"
FT REGION 1307..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 407
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 447
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 497
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 649
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 668
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 707
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1015
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1025
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1059
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1449 AA; 162091 MW; 70E3A155C4185D74 CRC64;
MWPNSNLNAV LLILAVLACP TSSQHVPLAM ANSTSNQVPT DPGFMPLQQS PGSVFFVHHN
QQNAMQLRHS MEGKLRNIRN TELRVAKIQE IFDSMHFSSA KGASNTRQAS SNDSNVVNPQ
LQRDLQLFSE RLSKKIQKAT YVVLELRELL RYNLTKVWQY SYDDEDDESE SEMDLEMELE
DLHARNTASP TDEHVQLYLN TQIESCQPDY ETDLEYGSSS TQSIHYNRQQ IQILNYLKSD
DARATFLNEN NARSLAVNGY ISNQLVLLKR RLSRSDAENS NSKPISGNHF KHIYFLSNSD
GASASLHFRQ LYVSAIKQKF VLFLIDVGSA LSAELFDLSK SFVHEMLQLL EDTDKVSLVT
VASEANFMSL EAFPAEAGHG IYSATRAHKE EIISFINSLS RAQAFTNHSL GFEYSFELLH
RLQQSGMINT AEQPVEFVYI TRGLLTNLSD AMAVLRVVAD GQRRLRAPVI INTCAVVLDE
KRIMYEKQFL NDVASQNYTK YEIDVASWWP SGQEASELVG RFYVLSKMHA ETSLPQTSSR
IFGPLFQERY LSDTLEVHPP VVDADSGDVL VSITHAVPPY GVVGVNLYLS DLLEDLLNYP
STTSSAKQGL GYAFLLDRST GNTLAHPAFP RPLIQRETSY PVNIAYLENA TDFSSHIRDR
LLREESGNVT TDVYVGRQRL QRTYYWQSVL GFYVLCLVSS GGDTLRNVSS TQRYNLKDTV
SNYEPGYYGE SMDLLYHRLD LNQGGSAPPK TCRYFRQVAT MDAPTLFLSA AAFESPFGFL
HNNRPRTQLR HVESIMAYLR DSSGLLANMG LRPSIRHEVG VLYQAMQQLR RRHQDARGSL
RSHVIRRYIA SVSGVLQLYP GCLLSSSYDP TRRPWFRQAI AQPGKIVSTA PYLDAGGAGY
IITIAHTIFE GKAHALHSAQ QDRPVAVVAL DVPYAFYYRL ILEGTPICQL PHIKCLLFEH
EGYLLAHPSM LQPATLTKNQ RRPHEHLTHK ESYLANDMLN HGQLVRKLGC ASYQNRTLQR
YYAFNTSLSS ILGNVVHGER TKYAIALIRG SNLFAAVLNS SCDGGAFCPC STIDRECLNC
KRMDQTDCEC PCECPMVGDS SSPSSLMYFA NYTRQFPYCP PPSEHFIALP PTTQLLSTLP
NCPGSAGICE TYSTQRECLG VMGCEWCQLD VDGNSFSTSF CSSQASCFNG VLASLTPYGE
LDEMELLAAH NPQREQHAYS AFGPLGGAIV VLVMVIGFAI YCYRHNLDAQ TQEHFYVDSV
QEENYGLPLS RFNFDDCKAH DEPPLGGGYD HASAQRQLMH AADISPYHVS SGSSYRRPPN
GESDHGYSTM TPHEDSSDQQ CFTLAEPLLL HDKRHSKSDT MSISTSISSP TNRQQSSSQP
NTHPYLSNQP TSKTERYKQV QATPSPCRGT PAGGSVYGQT TLPLEGDKTR PHYILAPVTV
HRHMETAES
