ID   VAT1L_MOUSE             Reviewed;         417 AA.
AC   Q80TB8; Q6PGM9;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Synaptic vesicle membrane protein VAT-1 homolog-like;
DE            EC=1.-.-.-;
GN   Name=Vat1l; Synonyms=Kiaa1576;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT   The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390; THR-391; THR-393 AND
RP   SER-394, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC65809.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK122527; BAC65809.1; ALT_INIT; mRNA.
DR   EMBL; BC056927; AAH56927.1; -; mRNA.
DR   CCDS; CCDS22689.1; -.
DR   RefSeq; NP_766604.2; NM_173016.3.
DR   AlphaFoldDB; Q80TB8; -.
DR   SMR; Q80TB8; -.
DR   BioGRID; 234760; 3.
DR   IntAct; Q80TB8; 1.
DR   STRING; 10090.ENSMUSP00000053431; -.
DR   iPTMnet; Q80TB8; -.
DR   PhosphoSitePlus; Q80TB8; -.
DR   MaxQB; Q80TB8; -.
DR   PaxDb; Q80TB8; -.
DR   PeptideAtlas; Q80TB8; -.
DR   PRIDE; Q80TB8; -.
DR   ProteomicsDB; 297911; -.
DR   Antibodypedia; 30406; 163 antibodies from 19 providers.
DR   DNASU; 270097; -.
DR   Ensembl; ENSMUST00000049509; ENSMUSP00000053431; ENSMUSG00000046844.
DR   GeneID; 270097; -.
DR   KEGG; mmu:270097; -.
DR   UCSC; uc009noa.1; mouse.
DR   CTD; 57687; -.
DR   MGI; MGI:2142534; Vat1l.
DR   VEuPathDB; HostDB:ENSMUSG00000046844; -.
DR   eggNOG; KOG1198; Eukaryota.
DR   GeneTree; ENSGT00940000159184; -.
DR   HOGENOM; CLU_026673_3_1_1; -.
DR   InParanoid; Q80TB8; -.
DR   OMA; INYRTDR; -.
DR   OrthoDB; 1085436at2759; -.
DR   PhylomeDB; Q80TB8; -.
DR   TreeFam; TF314255; -.
DR   BioGRID-ORCS; 270097; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Vat1l; mouse.
DR   PRO; PR:Q80TB8; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q80TB8; protein.
DR   Bgee; ENSMUSG00000046844; Expressed in habenula and 196 other tissues.
DR   ExpressionAtlas; Q80TB8; baseline and differential.
DR   Genevisible; Q80TB8; MM.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Pfam; PF08240; ADH_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Phosphoprotein; Reference proteome.
FT   CHAIN           1..417
FT                   /note="Synaptic vesicle membrane protein VAT-1 homolog-
FT                   like"
FT                   /id="PRO_0000160923"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         390
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         391
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         393
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         394
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   417 AA;  45817 MW;  604E25BDFC698CB2 CRC64;
     MAKEGVEKAE ETEQMIEKET SKEPAEGGDG SHRLGDAQEM RAVVLAGFGG LNKLRLSRKA
     MPEPQDGELK IRVKACGLNF IDLMVRQGNI DNPPKTPLVP GFECSGIVEA LGDSVKGYEI
     GDRVMAFVNY NAWAEVVCTP VEFVYKIPDD MSFSEAAAFP MNFVTAYTML FEIANLREGM
     SVLVHSAGGG VGQAVAQLCS TVPNVTVFGT ASTFKHEAIK DSVTHLFDRN ADYVQEVKRI
     SAEGVDIVLD CLCGDNTGKG LSLLKPLGTY ILYGSSNMVT GETKSFFSFA KSWWQVEKVN
     PIKLYEENKV IAGFSLLNLL FKQGRSGLIR GVVEKLIGLY NQKKIKPVVD SLWALEEVKE
     AMQRIHDRGN IGKLILDVEK TPTPLMANDS TETSEAGEEE EDHEGDSENK ERMPFIQ