ID   VAT1_DANRE              Reviewed;         484 AA.
AC   Q8JFV8; Q5SF06; Q6NYU0;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Synaptic vesicle membrane protein VAT-1 homolog;
DE            EC=1.-.-.-;
GN   Name=vat1 {ECO:0000312|EMBL:AAH66463.1}; ORFNames=si:dz163l24.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS37669.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=15533823; DOI=10.1016/j.modgep.2004.06.002;
RA   Loeb-Hennard C., Cousin X., Prengel I., Kremmer E.;
RT   "Cloning and expression pattern of vat-1 homolog gene in zebrafish.";
RL   Gene Expr. Patterns 5:91-96(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:CAD43425.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-474.
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH66463.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- DEVELOPMENTAL STAGE: First detected at the 8-somite stage in the
CC       trigeminal nuclei. At the 10-somite stage, also expressed in the
CC       forming hindbrain and in the neural tube. By the 20-somite stage,
CC       expression has extended to the dorsorostral, ventrorostral and
CC       ventrocaudal neuron clusters, the epiphysis and the hindbrain. At 24
CC       hours post-fertilization (hpf), detected in the developing gut. At
CC       later stages, expression is lost from the neural tube but continues in
CC       the brain and also appears in the retina and pharyngeal cavity.
CC       {ECO:0000269|PubMed:15533823}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000255}.
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DR   EMBL; AY534888; AAS37669.1; -; mRNA.
DR   EMBL; AL591669; CAD43425.1; -; Genomic_DNA.
DR   EMBL; BC066463; AAH66463.1; -; mRNA.
DR   AlphaFoldDB; Q8JFV8; -.
DR   SMR; Q8JFV8; -.
DR   IntAct; Q8JFV8; 1.
DR   MINT; Q8JFV8; -.
DR   STRING; 7955.ENSDARP00000073439; -.
DR   PaxDb; Q8JFV8; -.
DR   Ensembl; ENSDART00000078982; ENSDARP00000073439; ENSDARG00000056481.
DR   Ensembl; ENSDART00000193837; ENSDARP00000147945; ENSDARG00000111382.
DR   ZFIN; ZDB-GENE-030616-178; vat1.
DR   eggNOG; KOG1197; Eukaryota.
DR   GeneTree; ENSGT00940000157579; -.
DR   HOGENOM; CLU_026673_3_1_1; -.
DR   InParanoid; Q8JFV8; -.
DR   OMA; MQYVTAW; -.
DR   PhylomeDB; Q8JFV8; -.
DR   TreeFam; TF314255; -.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   PRO; PR:Q8JFV8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000056481; Expressed in brain and 28 other tissues.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0010637; P:negative regulation of mitochondrial fusion; IBA:GO_Central.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Pfam; PF08240; ADH_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..484
FT                   /note="Synaptic vesicle membrane protein VAT-1 homolog"
FT                   /id="PRO_0000160920"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        355
FT                   /note="S -> C (in Ref. 1; AAS37669)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   484 AA;  53563 MW;  C3026AD4AF64E02B CRC64;
     MSGEDAPAQQ QNAEEQKQQE TKTPAESPKT ESKPDPPPTS ASTEAAATAA AAADTPAPAA
     EKAPEEDTFT YRALVLTGYG GYDKVKLQVK KGKPALKSGE VMVRVKMCGL NFADLMARQG
     LYDRLPSPPV TPGMECSGVI EAVGEEVTDR KVGDKVLVLN RSGMWQEVVV VASTHTFLMP
     EGMSFEEAAA LPVNYITAYM MLFDFGHLRP NQSVLVHMAA GGVGIAATQL CKTVNDVTVF
     GTASASKHEV ISQGGVTHPI DYRTRDYVEE VRKISPKGLD IVLDPLGGSD THKGYNLLKP
     MGKLISYGAA NMLAGQKKNL FAVAKTWYQQ FSVHTLSLIQ GNRSVCGFHL GYLDSETELI
     DQAMTAVMDL YRQGKVKPRI DSTYHLEQVG DAMRRMQERN NIGKIILTTE PMKEEEKKEE
     AKKDEEKKDD KKKDDKKKDD KKKEDKKKDE AKKEEKKDEK KKEEAKKDDK KAEEKKEEVK
     KEEN