ID   VAT1_TETCF              Reviewed;         379 AA.
AC   P19333;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Synaptic vesicle membrane protein VAT-1;
DE            EC=1.-.-.-;
OS   Tetronarce californica (Pacific electric ray) (Torpedo californica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Tetronarce.
OX   NCBI_TaxID=7787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Electric lobe;
RX   PubMed=2483112; DOI=10.1016/0896-6273(89)90311-5;
RA   Linial M., Miller K., Scheller R.H.;
RT   "VAT-1: an abundant membrane protein from Torpedo cholinergic synaptic
RT   vesicles.";
RL   Neuron 2:1265-1273(1989).
CC   -!- FUNCTION: May play a central role in the functions mediated by specific
CC       classes of synaptic vesicles.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane.
CC   -!- TISSUE SPECIFICITY: Cholinergic synaptic vesicles.
CC   -!- MISCELLANEOUS: Synthesized in the neuronal cell bodies and transported
CC       to the terminals. Each vesicle contains approximately 28 molecules of
CC       VAT-1.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
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DR   PIR; JN0013; JN0013.
DR   AlphaFoldDB; P19333; -.
DR   SMR; P19333; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Direct protein sequencing; Membrane; Oxidoreductase;
KW   Phosphoprotein; Synapse.
FT   CHAIN           1..379
FT                   /note="Synaptic vesicle membrane protein VAT-1"
FT                   /id="PRO_0000160921"
FT   MOD_RES         273
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  41593 MW;  FA4ADA17E657F09C CRC64;
     MTGEEVKEPK EQQEITEVKE QEPEISYNAI VLNGVGGYDK VKVEVKKGVP TLKSDEILVR
     VQACGLNFSD LLVRQGAFGK HHSLGTECAG VVEAIGDLVI DRKVGDKIIM LNIDGGLWTE
     LVVTTVNRTF LMPDGMSFQE AAAISVNYTA AYVMIYDFAN LRPSQSILIH MAAGGVGIAA
     TQLCKLVHDV TIFGTASPSK HETIKENGVT YPIDYTTLDY AEEVRKIAPK GVDIVLDPLG
     GADDSKGFGL LKPLGKLVLY GSANQVTAPK RSSLAAAKVW WHKFNIDALQ LINSNKAVCG
     FHLGRTDPDH VAEVIRKLIS LYKEGKIKPK VDSVWSFEQV GDAMRHMRNT RTLEKSSWSL
     KSRQLMPQLE IKSVSKRQG