ID   VATA1_CLOTE             Reviewed;         592 AA.
AC   Q896K4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=V-type ATP synthase alpha chain 1 {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A 1 {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA1 {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=CTC_00999;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The V-type alpha chain is a catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR   EMBL; AE015927; AAO35586.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q896K4; -.
DR   SMR; Q896K4; -.
DR   STRING; 212717.CTC_00999; -.
DR   EnsemblBacteria; AAO35586; AAO35586; CTC_00999.
DR   KEGG; ctc:CTC_00999; -.
DR   HOGENOM; CLU_008162_3_1_9; -.
DR   OMA; RIVKTFW; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0045259; C:proton-transporting ATP synthase complex; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..592
FT                   /note="V-type ATP synthase alpha chain 1"
FT                   /id="PRO_0000322464"
FT   BINDING         233..240
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   592 AA;  65364 MW;  16488D651334AE1C CRC64;
     MDLKTGRVVK VSGPLVVAEG MEEANLFDVV RVGDERLIGE IIEMREDKAS IQVYEETSGL
     GPGAPVVTTG APLSVELGPG LIEAMFDGIQ RPLDAIEAKA GDFITRGIDV PSLSREKVWH
     FNPTKKAGDK VETGDILGLV QETSVIEHRI MVPPGIKGEI ISLNEGDYTV IDKIGEIKTD
     KGIEDLTLMQ KWPVRRGRPY KRKLNPSAPM VTGQRVVDTF FPVTKGGTAC VPGPFGSGKT
     VVQHQLAKWA DAQIVVYIGC GERGNEMTDV LNEFPELKDP KTGESLMKRT VLIANTSNMP
     VAAREASIYT GITIGEYFRD MGYSIALMAD STSRWAEALR EMSGRLEEMP GEEGYPAYLG
     SRLAEFYERA GNVICLGQDG REGALTAIGA VSPPGGDLSE PVTQATLRIV KVFWGLDSQL
     AYRRHFPAIN WLNSYSLYLD KVGPWMNENV AEDWVELRQK AMALLQEEAN LQEIARLVGI
     DALSEEDRLK LEVAKSLRED YLQQNAFHDV DTYAPLNKQY RMLKAVLQFG DEARKALESG
     VYLKDILNLP VRDKIARAKY IDEKDILSID EISKELTKDI EDLISKGGIL DA