ID   VATA1_TREPA             Reviewed;         589 AA.
AC   O83441;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=V-type ATP synthase alpha chain 1;
DE            EC=7.1.2.2;
DE   AltName: Full=V-ATPase subunit A 1;
GN   Name=atpA1; OrderedLocusNames=TP_0426;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The V-type alpha chain is a catalytic subunit (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000305}.
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DR   EMBL; AE000520; AAC65412.1; -; Genomic_DNA.
DR   PIR; G71325; G71325.
DR   RefSeq; WP_010881874.1; NC_021490.2.
DR   AlphaFoldDB; O83441; -.
DR   SMR; O83441; -.
DR   STRING; 243276.TPANIC_0426; -.
DR   TCDB; 3.A.2.3.3; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR   EnsemblBacteria; AAC65412; AAC65412; TP_0426.
DR   GeneID; 57878951; -.
DR   KEGG; tpa:TP_0426; -.
DR   eggNOG; COG1155; Bacteria.
DR   HOGENOM; CLU_008162_1_1_12; -.
DR   OMA; RIVKTFW; -.
DR   OrthoDB; 875807at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..589
FT                   /note="V-type ATP synthase alpha chain 1"
FT                   /id="PRO_0000144620"
FT   BINDING         239..246
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   589 AA;  65019 MW;  F890967333DAB14E CRC64;
     MTQTKGIVSA VNGNMVSVTF EGVVSLNEVG YVHVGNARLK AEIIRVRGRE AQLQVFEITR
     GVSVGDRVEF TGDLLSVELG PGLLGQVYDG LQNPLPLLAE KVGYFLERGV YLPALSRTSE
     WMFTPHVSVG ERVVRGDVLG YTPEGALKHR IMVPFHMGDS YEVVFIQTAG TYRVHDVIAR
     VRDAQGHEHE LTMAFRWPVK RPVHCYAERL KPTEPLVTSI RTIDTFFPVA KGGTYCIPGP
     FGAGKTVLQH STSRNADVDV VVIAACGERA GEVVETLREF PDLTDPRTGR SLMERTVIVC
     NTSSMPVASR EASVYTGVTL AEYYRQMGLD VLLLADSTSR WAQALREMSG RLEEIPGEEA
     FPAYLESCIA AFYERAGVVR LRSGEKGSVT IGGTVSPAGG NFEEPVTQAT LKVVGAFHGL
     SRERSDARRY PAVHPLDSWS KYPSVLDARA VAYGRSFLRR GAEVEQMMRV VGEEGTSMED
     FLVYLKGSFL DSVYLQQNSF DTVDSAVPVA RQKHCYAIVM RVLGSVLAFE SKDDARAYFS
     KLGHMFIDYN CCAWNSEAFV EKEKEIRAFL QGESTKIDSE AEGIIRGME