ID   VATA2_METHJ             Reviewed;         584 AA.
AC   Q2FL43;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=V-type ATP synthase alpha chain 2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A 2 {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA2 {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=Mhun_1759;
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1;
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The archaeal alpha chain is a catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR   EMBL; CP000254; ABD41480.1; -; Genomic_DNA.
DR   RefSeq; WP_011448744.1; NC_007796.1.
DR   AlphaFoldDB; Q2FL43; -.
DR   SMR; Q2FL43; -.
DR   STRING; 323259.Mhun_1759; -.
DR   EnsemblBacteria; ABD41480; ABD41480; Mhun_1759.
DR   GeneID; 3924709; -.
DR   KEGG; mhu:Mhun_1759; -.
DR   eggNOG; arCOG00868; Archaea.
DR   HOGENOM; CLU_008162_3_1_2; -.
DR   OMA; TAFVQVY; -.
DR   OrthoDB; 6736at2157; -.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..584
FT                   /note="V-type ATP synthase alpha chain 2"
FT                   /id="PRO_0000322483"
FT   BINDING         227..234
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   584 AA;  65195 MW;  C78E54C3755723ED CRC64;
     MITGTIARIS GPVITARNMT GSRMYDVVWV GRAALPGEII RLEGDEAVIQ VYEDTTGLMI
     HEPVENTGVP LSVELGPGLL ASIYDGVQRP LPALYAKSGN YISRGIMVPG LDREKRWAFN
     PVKKAGEMVQ TGDVLGTVQE FHLVHSIMVP PGVSGEIKTI ASGEFTVTDV VCTLADGTEI
     TMLQRWPVRK GRPFVKRLDP EVPLLTGQRV FDTMFPLVKG GTAMIPGGFG TGKTVSEQTL
     AKWADTQVVV YIGCGERGNE MTDVLTEFPE LTDPRTGYPL IERTIMIANT SNMPVAAREA
     SIYTGITIAE YYRDMGMDVA LLADSTSRWG EALREVSGRL EEMPGEEGYP AYLATRLAAF
     YERAGRVICA GSEEKTGSVT IIGAVSPPGG DFSEPITQNT LRIAGTFWAL DANLAYRRHY
     PSVNWIRSYS LYLEDVEDWF SEKVARDWYQ FRGRAMYILQ KEVELQEIVQ LVGPDALPDK
     EKVVLEIAKI IREDFLQQSA YSDDDSFCPL EKQYWMLKII IWYYDAIRAA MRRNVPLRQL
     LSIPARSEIA RMKEQRDLDR LKRLSDIVWE QTENLEVQTC STAA