CAHD1_MOUSE
ID CAHD1_MOUSE Reviewed; 1288 AA.
AC Q6PDJ1; A2A8W3; Q6PFZ0; Q6ZPM4; Q8BNP3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=VWFA and cache domain-containing protein 1;
DE Short=Cache domain-containing protein 1;
DE Flags: Precursor;
GN Name=Cachd1; Synonyms=Kiaa1573, Vwcd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-307.
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 104-922 (ISOFORM 2).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- FUNCTION: May regulate voltage-dependent calcium channels.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PDJ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PDJ1-2; Sequence=VSP_028073;
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM20140.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM22543.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL670223; CAM20139.1; -; Genomic_DNA.
DR EMBL; AL627083; CAM20139.1; JOINED; Genomic_DNA.
DR EMBL; AL670223; CAM20140.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL627083; CAM20140.1; JOINED; Genomic_DNA.
DR EMBL; AL627083; CAM22542.1; -; Genomic_DNA.
DR EMBL; AL670223; CAM22542.1; JOINED; Genomic_DNA.
DR EMBL; AL627083; CAM22543.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL670223; CAM22543.1; JOINED; Genomic_DNA.
DR EMBL; BC058676; AAH58676.1; -; mRNA.
DR EMBL; BC057356; AAH57356.1; -; mRNA.
DR EMBL; BC080313; AAH80313.1; -; mRNA.
DR EMBL; AK080923; BAC38080.1; -; mRNA.
DR EMBL; AK129397; BAC98207.1; -; Transcribed_RNA.
DR CCDS; CCDS18391.1; -. [Q6PDJ1-1]
DR RefSeq; NP_932154.1; NM_198037.1. [Q6PDJ1-1]
DR AlphaFoldDB; Q6PDJ1; -.
DR SMR; Q6PDJ1; -.
DR BioGRID; 236077; 2.
DR STRING; 10090.ENSMUSP00000030257; -.
DR GlyConnect; 2827; 1 N-Linked glycan (1 site).
DR GlyGen; Q6PDJ1; 2 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q6PDJ1; -.
DR PhosphoSitePlus; Q6PDJ1; -.
DR MaxQB; Q6PDJ1; -.
DR PaxDb; Q6PDJ1; -.
DR PeptideAtlas; Q6PDJ1; -.
DR PRIDE; Q6PDJ1; -.
DR ProteomicsDB; 273900; -. [Q6PDJ1-1]
DR ProteomicsDB; 273901; -. [Q6PDJ1-2]
DR Antibodypedia; 2535; 37 antibodies from 14 providers.
DR DNASU; 320508; -.
DR Ensembl; ENSMUST00000030257; ENSMUSP00000030257; ENSMUSG00000028532. [Q6PDJ1-1]
DR GeneID; 320508; -.
DR KEGG; mmu:320508; -.
DR UCSC; uc008tvg.1; mouse. [Q6PDJ1-1]
DR CTD; 57685; -.
DR MGI; MGI:2444177; Cachd1.
DR VEuPathDB; HostDB:ENSMUSG00000028532; -.
DR eggNOG; KOG2353; Eukaryota.
DR GeneTree; ENSGT00940000157568; -.
DR InParanoid; Q6PDJ1; -.
DR OMA; KSFVHEM; -.
DR OrthoDB; 260352at2759; -.
DR PhylomeDB; Q6PDJ1; -.
DR TreeFam; TF315824; -.
DR BioGRID-ORCS; 320508; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Cachd1; mouse.
DR PRO; PR:Q6PDJ1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q6PDJ1; protein.
DR Bgee; ENSMUSG00000028532; Expressed in choroid plexus epithelium and 258 other tissues.
DR ExpressionAtlas; Q6PDJ1; baseline and differential.
DR Genevisible; Q6PDJ1; MM.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF08399; VWA_N; 1.
DR SUPFAM; SSF103190; SSF103190; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Calcium transport; Glycoprotein;
KW Ion transport; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..49
FT /evidence="ECO:0000255"
FT CHAIN 50..1288
FT /note="VWFA and cache domain-containing protein 1"
FT /id="PRO_0000304662"
FT TOPO_DOM 50..1109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1110..1130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1131..1288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 242..457
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 467..546
FT /note="Cache 1"
FT DOMAIN 786..867
FT /note="Cache 2"
FT REGION 1157..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 823..828
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14621295"
FT /id="VSP_028073"
SQ SEQUENCE 1288 AA; 143812 MW; CF4ABE98727BABF5 CRC64;
MAREPEEEET VRPAAVVRRC PRCPGWPGAP RPPLWLLCLV ACWILGAVAD ADFSILDEAQ
VLASQMRRLA AEELGVVTMQ RIFNSLVYTE KISNGESEVQ QLAKKIREKF NRYLDVVNRN
KQVVEASYTA HLTSPLTAIQ DCCTIPPSMM EFDGNFNTNV SRTVSCDRLS TTVNSRAFNP
GRDLNSVLAD NLKSNPGIKW QYFSSEEGIF TVFPAHKFRC KGSYEHRSRP IYVSTVRPQS
KHIVVILDHG ASVTDTQLQI AKDAAQVILS AIDEHDKISV LTVADAVRTC SLDQCYKTYL
SPATSETKRK MSTFVSSVKP SDSPTQHAVG FHRAFQLIRS TSNSTRFQAN TDMVIIYLSA
GITSKDSSEE DKKATLRVIN EENGFLNNSV MILTYALMND GVTGLKELAF LRDLAEQNSG
KYGIPDRTAL PVIKGSMMVL NQLSNLETTV GRFYTNLPNR MIDEAVFSLP FSDEMGDGLI
MTVSKPCYFG NLLLGIVGVD VNLAYILEDV TYYQDSLASY TFLIDDKGYT LMHPSLTRPY
LLSEPPLHTD IIHYENIPKF ELVRQNILSL PLGSQIITVP VNSSLSWHIN KLRETGKEAY
NVSYAWKMVQ DTSFILCIVV IQPEIPVKQL KNLNTVPSSK LLYHRLDLLG QPSACLHFKQ
LATLESPTVM LSAGSFSSPY EHLSQPETKR MVEHYTAYLS DNTRLIANPG LKFSVRNEVM
ATSHVTDEWM TQMEMSSLNT YIVRRYIATP NGVLRIYPGS LMDKAFDPTR RQWYLHAVAN
PGLISLTGPY LDVGGAGYVV TISHTIHSSS TQLSSGHTVA VMGIDFTLRY FYKVLMDLLP
VCNQDGGNKI RCFIMEDRGY LVAHPTLVDP KGHAPLEQQH ITHKEPLVAN DILNHPNFVK
KNLCNSFSDR TVQRSYKFNT SLVGDLTNLV HGSHCSKYRL TRIPGTNAFV GIVNETCDSL
AFCACSMVDR LCLNCHRMEQ NECECPCECP LEVNECTGNL TNAENRNPSC EVHQEPVTYT
AIDPGLQDAL QQCVNSRCNQ RMESGDCFGV LDCEWCVVDS DGKTHLDKSY CAPQKECFGG
IVGAKSPYVD DMGAIGDEVI TLNMIKSAPV GPVAGGIMGC IMVLVLAVYA YRHQIHRRSH
QHMSPLAAQE MSVRMSNLEN DRDERDDDSH EDRGIISNTR FIAAVMERHV HSPERRRRYW
GRSGTESDHG YSTMSPQEDS ENPPCNNDPL SAGVDVGNHD DDLDLDTPPQ TAALLSHKFH
HYRPHHPTLH HSHHLQAAVT VHTVDAEC
