VATA_ACET2
ID VATA_ACET2 Reviewed; 589 AA.
AC A3DHP0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=Cthe_2267;
OS Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC
OS 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Oscillospiraceae;
OC Acetivibrio.
OX NCBI_TaxID=203119;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL
RC B-4536 / VPI 7372;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D.,
RA Newcomb M., Richardson P.;
RT "Complete sequence of Clostridium thermocellum ATCC 27405.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC across the membrane. The V-type alpha chain is a catalytic subunit.
CC {ECO:0000255|HAMAP-Rule:MF_00309}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR EMBL; CP000568; ABN53469.1; -; Genomic_DNA.
DR RefSeq; WP_003513515.1; NC_009012.1.
DR AlphaFoldDB; A3DHP0; -.
DR SMR; A3DHP0; -.
DR STRING; 203119.Cthe_2267; -.
DR PRIDE; A3DHP0; -.
DR EnsemblBacteria; ABN53469; ABN53469; Cthe_2267.
DR KEGG; cth:Cthe_2267; -.
DR eggNOG; COG1155; Bacteria.
DR HOGENOM; CLU_008162_3_1_9; -.
DR OMA; RIVKTFW; -.
DR OrthoDB; 875807at2; -.
DR Proteomes; UP000002145; Chromosome.
DR GO; GO:0045259; C:proton-transporting ATP synthase complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1140.10; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR InterPro; IPR031686; ATP-synth_a_Xtn.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR020003; ATPase_a/bsu_AS.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022878; V-ATPase_asu.
DR PANTHER; PTHR43607; PTHR43607; 1.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR SUPFAM; SSF50615; SSF50615; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW Nucleotide-binding; Reference proteome; Translocase; Transport.
FT CHAIN 1..589
FT /note="V-type ATP synthase alpha chain"
FT /id="PRO_1000059340"
FT BINDING 232..239
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ SEQUENCE 589 AA; 65364 MW; 4479E74E5C8B1E8D CRC64;
MSQGTIVKVS GPLVIAEGMR DANMFDVVRV SEHRLIGEII EMHGDRASIQ VYEETAGLGP
GEPVVSTGAP LSVELGPGLI ENIFDGIQRP LVKMREMVGS NITRGIDVTA LDRSKKWDFQ
PTVKKGDKVT AGDVIGKVQE TSIVEHRIMV PYGVQGTIEE IKSGSFTVEE TVAKVRTENN
ELVDICMMQK WPVRIGRPYR EKLPPNAPLV TGQRVIDTLF PLAKGGVAAV PGPFGSGKTV
VQHQLAKWAD ADIVVYIGCG ERGNEMTDVL KEFPELKDPK TGESLMKRTV LIANTSDMPV
AAREASIYTG MTIAEYFRDM GYSVALMADS TSRWAEALRE MSGRLEEMPG EEGYPAYLGS
RLAQFYERAG RVVCLGSDGR EGALTAIGAV SPPGGDLSEP VTQATLRIIK VFWGLDSSLA
YRRHFPAINW LQSYSLYLDI IGKWISENIS RDWETLRSDT MRILQEEAEL EEIVRLVGVD
ALSPSDRLTL EAAKSIREDY LHQNAFHEVD TYTSLNKQYR MLKLILGFYY SGKKALEAGV
SIKELFELPV REKIGRAKYT PEDQVNSHFN EIEKELNEQI EALIAKEVQ
