ID   VATA_AERPE              Reviewed;         597 AA.
AC   Q9YF35;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=V-type ATP synthase alpha chain;
DE            EC=7.1.2.2;
DE   AltName: Full=V-ATPase subunit A;
GN   Name=atpA; OrderedLocusNames=APE_0405.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The archaeal alpha chain is a catalytic subunit
CC       (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000305}.
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DR   EMBL; BA000002; BAA79361.2; -; Genomic_DNA.
DR   PIR; E72733; E72733.
DR   AlphaFoldDB; Q9YF35; -.
DR   SMR; Q9YF35; -.
DR   STRING; 272557.APE_0405.1; -.
DR   PRIDE; Q9YF35; -.
DR   EnsemblBacteria; BAA79361; BAA79361; APE_0405.1.
DR   KEGG; ape:APE_0405.1; -.
DR   PATRIC; fig|272557.25.peg.302; -.
DR   eggNOG; arCOG00868; Archaea.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0033178; C:proton-transporting two-sector ATPase complex, catalytic domain; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR005726; ATP_synth_asu_arc.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01043; ATP_syn_A_arch; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..597
FT                   /note="V-type ATP synthase alpha chain"
FT                   /id="PRO_0000144591"
FT   BINDING         241..248
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  66970 MW;  35101B6E1C7BCBC0 CRC64;
     MAVKGSIVRI SGPLVVAEGM SGAQMYEMVY VGEDRLIGEI TRIRGDRAFI QVYESTSGLK
     PGEPVVGTGA PLSVELGPGL LGTIYDGVQR PLPIIAEKVA EVDPRRRMFV ERGIQAPPLP
     RDRKFHFKPE PLKEGDKVEG GDALGRVPET SLIEHVVMVP PGIRGRLKWL ASEGDYSVED
     TIAVVERDGR DVEIRMHQRW PVRIPRPFKE KLEPQLPLIT GVRIIDTFFP MAKGGTGAVP
     GGFGTGKTVT LHSLAQWSEA RVVIYIGCGE RGNEMTEVLE RFPQYKDPWT GKPLMDRTVL
     IANTSNMPVA AREASIYVGI TIAEYYRDMG YDVLLVADST SRWAEALREI AGRLEEMPAE
     EGYPSYLASR LAEFYERAGR VKALGSPERS GSVTVVGAVS PPGGDFSEPV TSHTTRFIRV
     FWALDTKLAY SRHYPAINWL MSYSAYVDLV TQWWHENVDK RWREYRDEAM DILLRESELQ
     EIVRLVGTEG LDEKDKMVLE TARLIKDGFL KQNAFDPIDA FATPQKQFRL LKMIMDIHRK
     SLELIEKGVT TQQILQALGR LYIDIVKAKF TIPNDQLEKI DEIRDRALKA LDELVSG