VATA_BORBZ
ID VATA_BORBZ Reviewed; 575 AA.
AC B7J127;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=BbuZS7_0094;
OS Borreliella burgdorferi (strain ZS7) (Borrelia burgdorferi).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=445985;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZS7;
RX PubMed=20935092; DOI=10.1128/jb.01158-10;
RA Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA Mongodin E.F., Luft B.J.;
RT "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL J. Bacteriol. 193:1018-1020(2011).
CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC across the membrane. The V-type alpha chain is a catalytic subunit.
CC {ECO:0000255|HAMAP-Rule:MF_00309}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR EMBL; CP001205; ACK74625.1; -; Genomic_DNA.
DR RefSeq; WP_012597331.1; NC_011728.1.
DR AlphaFoldDB; B7J127; -.
DR SMR; B7J127; -.
DR EnsemblBacteria; ACK74625; ACK74625; BbuZS7_0094.
DR KEGG; bbz:BbuZS7_0094; -.
DR HOGENOM; CLU_008162_1_1_12; -.
DR OMA; RIVKTFW; -.
DR OrthoDB; 875807at2; -.
DR Proteomes; UP000006901; Chromosome.
DR GO; GO:0045259; C:proton-transporting ATP synthase complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1140.10; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR InterPro; IPR031686; ATP-synth_a_Xtn.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022878; V-ATPase_asu.
DR PANTHER; PTHR43607; PTHR43607; 1.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR SUPFAM; SSF50615; SSF50615; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..575
FT /note="V-type ATP synthase alpha chain"
FT /id="PRO_1000119523"
FT BINDING 238..245
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ SEQUENCE 575 AA; 64093 MW; 9E5A650CE14FE26A CRC64;
MNTKGKVVGV NGNLVTIEVE GSVFMNEVLF VKTAGRNLKA EVIRIRGNEV DAQVFELTKG
ISVGDLVEFT DKLLTVELGP GLLTQVYDGL QNPLPELAIQ CGFFLERGVY LRPLNKDKKW
NFKKTSKVGD IVIAGDFLGF VIEGTVHHQI MIPFYKRDSY KIVEIVSDGD YSIDEQIAVI
EDDSGMRHNI TMSFHWPVKV PITNYKERLI PSEPMLTQTR IIDTFFPVAK GGTFCIPGPF
GAGKTVLQQV TSRNADVDVV IIAACGERAG EVVETLKEFP ELMDPKTGKS LMDRTCIICN
TSSMPVAARE ASVYTAITIG EYYRQMGLDI LLLADSTSRW AQAMREMSGR LEEIPGEEAF
PAYLESVIAS FYERAGIVVL NNGDIGSVTV GGSVSPAGGN FEEPVTQATL KVVGAFHGLT
RERSDARKFP AISPLESWSK YKGVIDQKKT EYARSFLVKG NEINQMMKVV GEEGISNDDF
LIYLKSELLD SCYLQQNSFD SIDAAVSSER QNYMFDIVYN ILKTNFEFSD KLQARDFINE
LRQNLLDMNL SSFKDHKFNK LEHALGELIN FKKVI