ID   VATA_CLOBL              Reviewed;         590 AA.
AC   A7GGL4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=CLI_2690;
OS   Clostridium botulinum (strain Langeland / NCTC 10281 / Type F).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Langeland / NCTC 10281 / Type F;
RA   Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D.,
RA   Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The V-type alpha chain is a catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABS41807.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000728; ABS41807.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041173237.1; NC_009699.1.
DR   AlphaFoldDB; A7GGL4; -.
DR   SMR; A7GGL4; -.
DR   EnsemblBacteria; ABS41807; ABS41807; CLI_2690.
DR   KEGG; cbf:CLI_2690; -.
DR   HOGENOM; CLU_008162_3_1_9; -.
DR   Proteomes; UP000002410; Chromosome.
DR   GO; GO:0045259; C:proton-transporting ATP synthase complex; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..590
FT                   /note="V-type ATP synthase alpha chain"
FT                   /id="PRO_0000322462"
FT   BINDING         231..238
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   590 AA;  65540 MW;  736A6829ECDCF7F8 CRC64;
     MKTGRVLKIS GPLVVAEGME EANIYDVVKV GEKRLIGEII EMREDRASIQ VYEETAGLAP
     GDPVITTGEP LSVELGPGLI EAMFDGIQRP LNAIKAKAGD FITRGVEVHS LDRDRKWHFT
     PVKKVGDTVE AGDVIGIVQE TSIVEHKIMV PYGIKGTIET IEEGDFTVVD TVAKVKDKDK
     VSDLIMMQKW PVRRGRPYGR KLNPVEPMIT GQRVIDTFFP VTKGGTACVP GPFGSGKTVV
     QHQLAKWADA QIVVYIGCGE RGNEMTDVLN EFPELKDPKT GEPLMKRTVL IANTSNMPVA
     AREASIYTGI TIGEYFRDMG YSVALMADST SRWAEALREM SGRLEEMPGD EGYPAYLGSR
     AADFYERAGK VLSLGSEGRE GALTVIGAVS PPGGDLSEPV TQATLRIVKV FWGLDSQLAY
     RRHFPAINWL NSYSLYLEKI SPWMDENVAS DWTALRTRAM SLLQEEANLE EIVRLVGIDA
     LSEKDRLKLE VAKSLREDYL QQNAFHEVDT YASLEKQYKM LKLVLFFYDE TQRALNAGIY
     LKELLDLEVR DKIARAKYIS EESIENIDAI FNELSEVIDE LISKGGIMNA