ID   VATA_GOSHI              Reviewed;         623 AA.
AC   P31405;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=V-type proton ATPase catalytic subunit A;
DE            Short=V-ATPase subunit A;
DE            EC=7.1.2.2;
DE   AltName: Full=V-ATPase 69 kDa subunit;
DE   AltName: Full=Vacuolar proton pump subunit alpha;
GN   Name=CVA69.24;
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=3635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8108515; DOI=10.1104/pp.102.2.679;
RA   Wilkins T.A.;
RT   "Vacuolar H(+)-ATPase 69-kilodalton catalytic subunit cDNA from developing
RT   cotton (Gossypium hirsutum) ovules.";
RL   Plant Physiol. 102:679-680(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 137-160.
RC   STRAIN=cv. Acala SJ2;
RA   Wilkins T.A., Wan C., Lu C.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic subunit of the peripheral V1 complex of vacuolar
CC       ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a
CC       variety of intracellular compartments in eukaryotic cells.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC       catalytic V1 complex (main components: subunits A, B, C, D, E, and F)
CC       attached to an integral membrane V0 proton pore complex (main
CC       component: the proteolipid protein).
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000305}.
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DR   EMBL; L03186; AAA33050.1; -; mRNA.
DR   EMBL; U06255; AAA16505.1; -; Genomic_DNA.
DR   EMBL; U06256; AAA16506.1; -; Genomic_DNA.
DR   EMBL; U06257; AAA16507.1; -; Genomic_DNA.
DR   EMBL; U06464; AAA16508.1; -; Genomic_DNA.
DR   RefSeq; NP_001314243.1; NM_001327314.1.
DR   AlphaFoldDB; P31405; -.
DR   SMR; P31405; -.
DR   STRING; 3635.P31405; -.
DR   PRIDE; P31405; -.
DR   GeneID; 107930394; -.
DR   KEGG; ghi:107930394; -.
DR   OMA; TAFVQVY; -.
DR   Proteomes; UP000189702; Genome assembly.
DR   GO; GO:0000325; C:plant-type vacuole; IBA:GO_Central.
DR   GO; GO:0009705; C:plant-type vacuole membrane; IDA:AgBase.
DR   GO; GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IDA:AgBase.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR   GO; GO:0090378; P:seed trichome elongation; IEP:AgBase.
DR   GO; GO:0090377; P:seed trichome initiation; IEP:AgBase.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR005725; ATPase_V1-cplx_asu.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01042; V-ATPase_V1_A; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Hydrogen ion transport; Ion transport; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..623
FT                   /note="V-type proton ATPase catalytic subunit A"
FT                   /id="PRO_0000144580"
FT   BINDING         252..259
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   623 AA;  68522 MW;  D322444CC4210D21 CRC64;
     MPAVYGSRLT TFEDSEKESE YGYVRKVSGP VVVADGMAGA AMYELVRVGH DNLIGEIIRL
     EGDSATIQVY EETAGLMVND PVLRTHKPLS VELGPGILGN IFDGIQRPLK TIAKRSGDVY
     IPRGVSVPAL DKDALWDFQP KKIGEGDLLT GGDLYATVFE NSLMQHHVAL PPDAMGKITY
     IAPPGQYSLK DTVLELEFQG VKKQFTMLQT WPVRTPRPVA TKLAADTPLL TGQRVLDALF
     PSVLGGTCAI PGAFGCGKTV ISQALSKYSN SDAVVYVGCG ERGNEMAEVL MDFPQLTMTL
     PDGREESVMK RTTLVANTSN MPVAAREASI YTGITIAEYF RDMGYNVSMM ADSTSRWAEA
     LREISGRLAE MPADSGYPAY LAARLASFYE RAGKVKCLGG PERTGSVTIV GAVSPPGGDF
     SDPVTSATLS IVQVFWGLDK KLAQRKHFPS VNWLISYSKY SGALESFYEK FDPDFISIRT
     KAREVLQRED DLNEIVQLVG KDALAETDKI TLETAKLLRE DYLAQNAFTP YDKFCPFYKS
     VWMMRNIVHF NALANQAVEK AAGMDGQKIT YSLIKHRLGD LFYRLVSQKF EDPAEGEEAL
     VAKFKKLNED LTAGFRALED ETR