ID   VATA_HALOH              Reviewed;         590 AA.
AC   B8CZG8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=Hore_19400;
OS   Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC   Bacteria; Firmicutes; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC   Halothermothrix.
OX   NCBI_TaxID=373903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H 168 / OCM 544 / DSM 9562;
RX   PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA   Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H.,
RA   Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT   "Genome analysis of the anaerobic thermohalophilic bacterium
RT   Halothermothrix orenii.";
RL   PLoS ONE 4:E4192-E4192(2009).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The V-type alpha chain is a catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR   EMBL; CP001098; ACL70687.1; -; Genomic_DNA.
DR   RefSeq; WP_015923656.1; NC_011899.1.
DR   AlphaFoldDB; B8CZG8; -.
DR   SMR; B8CZG8; -.
DR   STRING; 373903.Hore_19400; -.
DR   PRIDE; B8CZG8; -.
DR   EnsemblBacteria; ACL70687; ACL70687; Hore_19400.
DR   KEGG; hor:Hore_19400; -.
DR   eggNOG; COG1155; Bacteria.
DR   HOGENOM; CLU_008162_3_1_9; -.
DR   OMA; TAFVQVY; -.
DR   OrthoDB; 875807at2; -.
DR   Proteomes; UP000000719; Chromosome.
DR   GO; GO:0045259; C:proton-transporting ATP synthase complex; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..590
FT                   /note="V-type ATP synthase alpha chain"
FT                   /id="PRO_1000132882"
FT   BINDING         234..241
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   590 AA;  66713 MW;  B1F2D7AF84B70D6F CRC64;
     MDKKGEIVFV NGPVVKADKM NGFIMNELVY VGKERLIGEI IELEGDLATI QVYEETTEMQ
     PGEPVFSTGS PLSVELGPGI IGNIFDGIQR PLPVIAEKTG SFIKRGIEVN PLDRDREWTV
     SVKVKLGDRV KPGQVVAEVP ETSIVTHRVM VPPHLSGEVV EVVPNGKYTV DQEIVTVKDD
     KGNNHQIRLH QKWPVRRPRP CGERLPIKKP LLTGQRVFDT FFPLGMGGTA AIPGGFGAGK
     TMTQHQLAKW SSADIIVYVG CGERGNEMTD VLEEFPKLED PSTGKSMMER TVLIANTSNM
     PVAAREASIY TGITIAEFYR DMGYNVALMA DSTSRWAEAL REISGRLEEM PAEEGFPAYL
     PSRLAEFYER AGYVKTLGQD REGSISLIGA VSPPGGDFSE PVTQNTKRYV RCFWALDKSL
     ASARHFPAVN WLESYSEYLE DLSGWLKENI NEDWIKLRNM AMELLKEEDR LQEIVKLVGE
     DVLPDNQRLI LEVARLIKIG FLQQNAFSKV DRFATPEKQY WMLKIIMFLY EKARPLIKNN
     IPISRVKNNE LFSEVIKMKE NIPNGDLDKF KDLMARIEEY YNRLWENYQE