ID   VATA_METAR              Reviewed;         579 AA.
AC   Q0W363;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=UNCMA_10660;
GN   ORFNames=RCIX2030;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The archaeal alpha chain is a catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR   EMBL; AM114193; CAJ37180.1; -; Genomic_DNA.
DR   RefSeq; WP_012035394.1; NC_009464.1.
DR   AlphaFoldDB; Q0W363; -.
DR   SMR; Q0W363; -.
DR   STRING; 351160.RCIX2030; -.
DR   PRIDE; Q0W363; -.
DR   EnsemblBacteria; CAJ37180; CAJ37180; RCIX2030.
DR   GeneID; 5143316; -.
DR   KEGG; rci:RCIX2030; -.
DR   PATRIC; fig|351160.9.peg.1101; -.
DR   eggNOG; arCOG00868; Archaea.
DR   OMA; RIVKTFW; -.
DR   OrthoDB; 6736at2157; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0033178; C:proton-transporting two-sector ATPase complex, catalytic domain; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR005726; ATP_synth_asu_arc.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01043; ATP_syn_A_arch; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..579
FT                   /note="V-type ATP synthase alpha chain"
FT                   /id="PRO_1000059362"
FT   BINDING         229..236
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   579 AA;  64060 MW;  339E4E1E50AE2901 CRC64;
     MSQQGTIYRV AGPVVTAVGL NARMYDVVKV GNEGLMGEVI EIDNDKAIIQ VYEDTSGVRP
     GEPVENTGMP LSVELGPGLL TSIYDGIQRP LEVLKEKMGN FITRGVSAPG LSRTKKWKFV
     PVVKAGDKVK GGIVIGTVQE TKTIVHKIMV PPNVGETTIK DIKEGEFTVE DVIGHLENGT
     ELKLMHKWPV RVPRPYVEKL RPDIPLITGQ RVLDGLFPIA KGGTAAIPGP FGSGKTVTQQ
     QLAKWSDAEI VVYIGCGERG NEMTEVLAEF PHLTDPKTGN PLMDRTVLIA NTSNMPVAAR
     EASCYTGITI AEYYRDMGYG VSLMADSTSR WAEAMREISS RLEEMPGEEG YPAYLAARLS
     EFYERAGRVI TPIGKEGSVT VIGAVSPAGG DISEPVTQNT LRIVKVFWAL DAKLAQRRHF
     PSINWLNSYS LYQDSLKDWY DKNISPEWNQ LKAESMELLQ RESELQEIVQ LVGSDALPED
     QQLTIEIARM IREIFLQQNA YHEVDTYCSL DKQLKMLKSI MQFGAYARTA LASGVPMSKI
     LNLNSKNDLA KVKFEANYDA YLTKVNDDMK KEFKSLEAA