VATA_NANEQ
ID VATA_NANEQ Reviewed; 570 AA.
AC Q74MJ7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=NEQ103;
OS Nanoarchaeum equitans (strain Kin4-M).
OC Archaea; Nanoarchaeota; Candidatus Nanoarchaeia; Nanoarchaeales;
OC Nanoarchaeaceae; Nanoarchaeum.
OX NCBI_TaxID=228908;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kin4-M;
RX PubMed=14566062; DOI=10.1073/pnas.1735403100;
RA Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M.,
RA Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X., Mathur E.,
RA Ni J., Podar M., Richardson T., Sutton G.G., Simon M., Soell D.,
RA Stetter K.O., Short J.M., Noorderwier M.;
RT "The genome of Nanoarchaeum equitans: insights into early archaeal
RT evolution and derived parasitism.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003).
CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC across the membrane. The archaeal alpha chain is a catalytic subunit.
CC {ECO:0000255|HAMAP-Rule:MF_00309}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR EMBL; AE017199; AAR38958.1; -; Genomic_DNA.
DR PDB; 5BN3; X-ray; 2.00 A; A=1-570.
DR PDB; 5BN4; X-ray; 2.70 A; A=1-570.
DR PDB; 5BN5; X-ray; 3.00 A; A=1-570.
DR PDBsum; 5BN3; -.
DR PDBsum; 5BN4; -.
DR PDBsum; 5BN5; -.
DR AlphaFoldDB; Q74MJ7; -.
DR SMR; Q74MJ7; -.
DR STRING; 228908.NEQ103; -.
DR EnsemblBacteria; AAR38958; AAR38958; NEQ103.
DR KEGG; neq:NEQ103; -.
DR PATRIC; fig|228908.8.peg.108; -.
DR HOGENOM; CLU_008162_3_1_2; -.
DR OMA; RIVKTFW; -.
DR Proteomes; UP000000578; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1140.10; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR InterPro; IPR031686; ATP-synth_a_Xtn.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022878; V-ATPase_asu.
DR PANTHER; PTHR43607; PTHR43607; 1.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR SUPFAM; SSF50615; SSF50615; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP synthesis; ATP-binding; Hydrogen ion transport;
KW Ion transport; Nucleotide-binding; Reference proteome; Translocase;
KW Transport.
FT CHAIN 1..570
FT /note="V-type ATP synthase alpha chain"
FT /id="PRO_0000144602"
FT BINDING 223..230
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
FT STRAND 3..8
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 11..16
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:5BN3"
FT TURN 27..30
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 31..39
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 42..49
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 55..57
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 59..61
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 68..72
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:5BN4"
FT HELIX 87..94
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 96..98
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 114..120
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 131..137
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 140..145
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 152..157
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 160..162
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 169..171
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 174..176
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 180..183
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 205..208
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 218..222
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 229..239
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 243..251
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 254..263
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 264..266
FT /evidence="ECO:0007829|PDB:5BN3"
FT TURN 270..272
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 276..279
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 280..285
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 287..289
FT /evidence="ECO:0007829|PDB:5BN5"
FT HELIX 293..309
FT /evidence="ECO:0007829|PDB:5BN3"
FT TURN 310..312
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 314..320
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 322..335
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 342..344
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 349..357
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 361..364
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 370..379
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 382..384
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 389..395
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 398..401
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 406..410
FT /evidence="ECO:0007829|PDB:5BN3"
FT TURN 419..421
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 423..425
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 427..437
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 441..458
FT /evidence="ECO:0007829|PDB:5BN3"
FT TURN 459..461
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 472..487
FT /evidence="ECO:0007829|PDB:5BN3"
FT STRAND 493..495
FT /evidence="ECO:0007829|PDB:5BN5"
FT TURN 496..498
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 503..523
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 529..533
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 537..542
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 544..546
FT /evidence="ECO:0007829|PDB:5BN3"
FT HELIX 552..562
FT /evidence="ECO:0007829|PDB:5BN3"
SQ SEQUENCE 570 AA; 64688 MW; 73663BEAA3604648 CRC64;
MNRIISINGP LVIAKGKFSI FEVVRVGEEK LIGEVIGIEN DKAYIQVYED TNGLKVGEPV
FNTGKPLTIE LGPGLLANIF DGLGRPLKDI YEKTQSIYIP KGIDLPTLDR KKVWEFIPKK
KKGDTIKGGD IIGTVNENGF EHRIIVPPNV EGKIEEIYEG NFTIEETIAI VNGKPIKLYH
EWPIRKPRPY KEKLDYNYPF ITGTRVLDIM FPIAKGGSAA VPGPFGSGKT VLNQQIAKWA
DSDIVIYIGC GERGNEMTEV LEEFPKLKDP KTGKPLMYRT ILIANTSNMP IAAREASIYL
GATIGEYFRD QGYSVVVNAD STSRWAEALR EISSRLGEIP SEEGYPAYLL RKLAEFYERS
GRVRTLNDLE GSLTIIGAVS PPGGDFSEPV TQNTLRLVGA LWALDSKLAY KRHYPAINYL
ISYTKQWEFV KKYFEELYED VIEIREEFFA ILKRESELMD IVSIVGPDAL SDNEKIYLHM
GRIIREGFLQ QDAFDENDSY SPLEKTIELM RIIHKYYVTV KQLLGKIPLE EIEQKGIHEK
IIKLRYKSLK EFREEIKAIE QEILSLLNSQ
