ID   VATA_PARUW              Reviewed;         593 AA.
AC   Q6MAJ5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=pc1680;
OS   Protochlamydia amoebophila (strain UWE25).
OC   Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC   Candidatus Protochlamydia.
OX   NCBI_TaxID=264201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWE25;
RX   PubMed=15073324; DOI=10.1126/science.1096330;
RA   Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA   Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T.,
RA   Mewes H.-W., Wagner M.;
RT   "Illuminating the evolutionary history of chlamydiae.";
RL   Science 304:728-730(2004).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The V-type alpha chain is a catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR   EMBL; BX908798; CAF24404.1; -; Genomic_DNA.
DR   RefSeq; WP_011176226.1; NC_005861.1.
DR   AlphaFoldDB; Q6MAJ5; -.
DR   SMR; Q6MAJ5; -.
DR   STRING; 264201.pc1680; -.
DR   EnsemblBacteria; CAF24404; CAF24404; PC_RS08040.
DR   KEGG; pcu:PC_RS08040; -.
DR   eggNOG; COG1155; Bacteria.
DR   HOGENOM; CLU_008162_1_1_0; -.
DR   OMA; RIVKTFW; -.
DR   OrthoDB; 875807at2; -.
DR   Proteomes; UP000000529; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..593
FT                   /note="V-type ATP synthase alpha chain"
FT                   /id="PRO_0000322468"
FT   BINDING         246..253
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   593 AA;  66546 MW;  AF0581E4A7E2167F CRC64;
     MKTLETRKEK KAQGKVLKAF GNLLQVTFEG NIRQGEVAMV HVDNLQLKSE VIEILGNQAK
     IQVFEDTKGV RLGSLVSFTG DLLEAELGPG LLSSIFDGLQ NPLVDVADQA GLFLPKGIYL
     SALDRQRKWD FESSAKVGDV LFRGDRIGST KEGRFHHFIM VPFSLYGKYR LTWVINSGSY
     TVDTVVAKAI DESGQEHSFT MVQKWPVKNA LIHGEKIKPT KMMDTGERII DTQFPLMKGG
     TFCTPGPFGA GKTVLQHHLS KYAAVDIVLF VACGERAGEV VEVLREFPHL IDPHTDEALM
     KRTVIICNTS SMPVAARESS IYMGITIAEY YRQMGLDVLV LADSTSRWAQ ALREMSGRLE
     EIPGEEAFPA YLSSRIAEFY ERSGVVSLRH GKPGSITIGG AVSPAGGNFE EPVTQATLSV
     VGAFLGLSRA RSDSRRYPAI DPLLSWSKYV DTVGNELSHQ VDGWDQMVKR ARHILFNGNE
     IGKRMEVVGE EGISMEDMLT YLKAELYDFS YLQQNAFDKE DAYCPLKRQI ALFQLINQIF
     DTTFDFHTHD QAREFFLDLQ NRIKNMNFIS FDTEQYRKVF AEIKSIIEQQ SRK