ID   VATA_PYRAE              Reviewed;         593 AA.
AC   Q8ZYR1;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=V-type ATP synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00309};
DE            EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_00309};
DE   AltName: Full=V-ATPase subunit A {ECO:0000255|HAMAP-Rule:MF_00309};
GN   Name=atpA {ECO:0000255|HAMAP-Rule:MF_00309}; OrderedLocusNames=PAE0663;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane. The archaeal alpha chain is a catalytic subunit.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00309};
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000255|HAMAP-Rule:MF_00309}.
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DR   EMBL; AE009441; AAL62932.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZYR1; -.
DR   SMR; Q8ZYR1; -.
DR   STRING; 178306.PAE0663; -.
DR   EnsemblBacteria; AAL62932; AAL62932; PAE0663.
DR   KEGG; pai:PAE0663; -.
DR   PATRIC; fig|178306.9.peg.477; -.
DR   eggNOG; arCOG00868; Archaea.
DR   HOGENOM; CLU_008162_3_1_2; -.
DR   InParanoid; Q8ZYR1; -.
DR   OMA; RIVKTFW; -.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.1140.10; -; 1.
DR   Gene3D; 2.40.30.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR   InterPro; IPR031686; ATP-synth_a_Xtn.
DR   InterPro; IPR023366; ATP_synth_asu-like_sf.
DR   InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR   InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022878; V-ATPase_asu.
DR   PANTHER; PTHR43607; PTHR43607; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF02874; ATP-synt_ab_N; 1.
DR   Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR   SUPFAM; SSF50615; SSF50615; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; ATP-binding; Hydrogen ion transport; Ion transport;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..593
FT                   /note="V-type ATP synthase alpha chain"
FT                   /id="PRO_0000144603"
FT   BINDING         236..243
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00309"
SQ   SEQUENCE   593 AA;  66320 MW;  C3966BF19D7FBCE3 CRC64;
     MSGKIEYISG PVVKAELPGA RLYELVFVGE IKLFGEVVRI QGEKAFIQVY EDTTGLKPGE
     PVERTGEPLS AWLGPTIIGK IYDGVQRPLR NIEEISKNPF IARGIGYDKA PPLDLKAEFD
     FKPAVKPGEE VYPGDVLGSV KETEPMTHYI LYPPLPEHAP GVVEWIADGK YKVDDVIARV
     KTKRGVVEVK MWHKWPVRRP RPFKEKLPPV EPLITGVRTV DTMFPIAKGG TAAVPGPFGS
     GKTVMIRTLS MFAQSRFIIP VLCGERGNEA ADALQGLLKL KDPSTGRPLL ERTTIIVNTS
     NMPVAAREAS VYMGTTLGEY FRDQGYDVLV LADSTSRWAE AMREVALRIG EMPSEEGYPA
     YLPTRLAEFY ERAGRVVLYG SKERVGSLTI AASVSPPGGD FTEPVTSNTL RFIGAFWPLS
     PRLAYSRHYP AIDWLVAFSR YVDTVEVWWS KNVSPEWRRI RDALQSILVK EAELQEIVRI
     LGTEALSEYE KHILNVAFMI REGFLKQDAY NPVDTPSAPI KQFLLMKAIY TYYEEGLKAI
     ESGVPASVLR ELETVKRLPR LRMEVTNDVA KEELTKFIES LVAEIRATTN RRG