ID   CAHM2_BOVIN             Reviewed;         323 AA.
AC   Q2HJ63;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Calcium homeostasis modulator protein 2;
DE   AltName: Full=Protein FAM26B;
GN   Name=CALHM2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC       {ECO:0000250|UniProtKB:Q8IU99}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR   EMBL; BC113290; AAI13291.1; -; mRNA.
DR   RefSeq; NP_001039885.1; NM_001046420.1.
DR   AlphaFoldDB; Q2HJ63; -.
DR   SMR; Q2HJ63; -.
DR   STRING; 9913.ENSBTAP00000012820; -.
DR   PaxDb; Q2HJ63; -.
DR   PRIDE; Q2HJ63; -.
DR   Ensembl; ENSBTAT00000012820; ENSBTAP00000012820; ENSBTAG00000009719.
DR   GeneID; 537067; -.
DR   KEGG; bta:537067; -.
DR   CTD; 51063; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009719; -.
DR   VGNC; VGNC:26708; CALHM2.
DR   eggNOG; ENOG502QVU7; Eukaryota.
DR   GeneTree; ENSGT01030000234610; -.
DR   HOGENOM; CLU_069286_1_0_1; -.
DR   InParanoid; Q2HJ63; -.
DR   OMA; YTCALSE; -.
DR   OrthoDB; 833717at2759; -.
DR   TreeFam; TF329085; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000009719; Expressed in ureter and 104 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   InterPro; IPR029569; CALHM.
DR   InterPro; IPR029570; CALHM2.
DR   PANTHER; PTHR32261; PTHR32261; 1.
DR   PANTHER; PTHR32261:SF3; PTHR32261:SF3; 1.
DR   Pfam; PF14798; Ca_hom_mod; 1.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..323
FT                   /note="Calcium homeostasis modulator protein 2"
FT                   /id="PRO_0000247440"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  36113 MW;  3087AE79399A44B4 CRC64;
     MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFT VVAFHCPCSP ARNYLYGLAA
     IGVPALALFL IGVILNNHTW NLVAECQYRR TKNCSAAPNF LLLSSIVGRA AVAPVTWSVI
     SLLRGEAYVC ALSEFVNPHS LMVGERSFPV AHATEILARF PCGEGPANLS VFREEVSRRL
     KYESQLFGWL LIGVVAILVF LTKCLKHYCS PLSYRQEAYW AQYRANEDQL FQRTAEVHSR
     VLAANNVRRF FGFVALDKDD EELVAKFPVE GTQPRLQWNA ITGVYLYREN QGLPLYSRLH
     KWAQGVVGNG MTPDHVEMSL LPS