CAHM2_MOUSE
ID CAHM2_MOUSE Reviewed; 323 AA.
AC Q8VEC4; Q3TDQ7; Q8BT85; Q8C246;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Calcium homeostasis modulator protein 2;
DE AltName: Full=Protein FAM26B;
GN Name=Calhm2; Synonyms=Fam26b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25382.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK012923; BAC25382.1; ALT_FRAME; mRNA.
DR EMBL; AK089278; BAC40825.1; -; mRNA.
DR EMBL; AK170068; BAE41544.1; -; mRNA.
DR EMBL; BC019197; AAH19197.1; -; mRNA.
DR CCDS; CCDS29889.1; -.
DR RefSeq; NP_598507.3; NM_133746.5.
DR AlphaFoldDB; Q8VEC4; -.
DR SMR; Q8VEC4; -.
DR STRING; 10090.ENSMUSP00000047278; -.
DR PhosphoSitePlus; Q8VEC4; -.
DR SwissPalm; Q8VEC4; -.
DR MaxQB; Q8VEC4; -.
DR PaxDb; Q8VEC4; -.
DR PRIDE; Q8VEC4; -.
DR ProteomicsDB; 273902; -.
DR Antibodypedia; 18174; 21 antibodies from 12 providers.
DR DNASU; 72691; -.
DR Ensembl; ENSMUST00000035822; ENSMUSP00000047278; ENSMUSG00000033033.
DR GeneID; 72691; -.
DR KEGG; mmu:72691; -.
DR UCSC; uc008hur.2; mouse.
DR CTD; 51063; -.
DR MGI; MGI:1919941; Calhm2.
DR VEuPathDB; HostDB:ENSMUSG00000033033; -.
DR eggNOG; ENOG502QVU7; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_1_0_1; -.
DR InParanoid; Q8VEC4; -.
DR OMA; YTCALSE; -.
DR OrthoDB; 833717at2759; -.
DR PhylomeDB; Q8VEC4; -.
DR TreeFam; TF329085; -.
DR BioGRID-ORCS; 72691; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Calhm2; mouse.
DR PRO; PR:Q8VEC4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VEC4; protein.
DR Bgee; ENSMUSG00000033033; Expressed in spleen and 99 other tissues.
DR ExpressionAtlas; Q8VEC4; baseline and differential.
DR Genevisible; Q8VEC4; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR InterPro; IPR029569; CALHM.
DR InterPro; IPR029570; CALHM2.
DR PANTHER; PTHR32261; PTHR32261; 1.
DR PANTHER; PTHR32261:SF3; PTHR32261:SF3; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..323
FT /note="Calcium homeostasis modulator protein 2"
FT /id="PRO_0000186721"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 97
FT /note="A -> P (in Ref. 1; BAC25382)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="R -> S (in Ref. 1; BAC40825)"
FT /evidence="ECO:0000305"
FT CONFLICT 145..148
FT /note="DKGF -> IKLP (in Ref. 1; BAC25382)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 35823 MW; 65841AEDA006FD0D CRC64;
MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP ARNYLYGLTA
IGVPALALFL IGVILNNHTW NLVAECQYRR AKNCSAAPNF LLLSSILGRA AVAPVTWSVI
SLLRGEAYVC ALSEFVDPSS LTAGDKGFPP AHATEVLARF PCGEGPANLS SFREEVSRRL
KYESQLFGWL LIGVVAILVF LTKCLKHYCS PLSYRQEAYW AQYRTNEDQL FQRTAEVHSR
VLAANNVRRF FGFVALNKDD EELVAKFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH
KWAQGLTGNG TAPDNVEMAL LTA
