ID   CAHM2_RAT               Reviewed;         323 AA.
AC   Q5RJQ8;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Calcium homeostasis modulator protein 2;
DE   AltName: Full=Protein FAM26B;
GN   Name=Calhm2; Synonyms=Fam26b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC       {ECO:0000250|UniProtKB:Q8IU99}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR   EMBL; BC086540; AAH86540.1; -; mRNA.
DR   RefSeq; NP_001008307.1; NM_001008306.1.
DR   AlphaFoldDB; Q5RJQ8; -.
DR   SMR; Q5RJQ8; -.
DR   IntAct; Q5RJQ8; 1.
DR   MINT; Q5RJQ8; -.
DR   STRING; 10116.ENSRNOP00000027526; -.
DR   PaxDb; Q5RJQ8; -.
DR   Ensembl; ENSRNOT00000027526; ENSRNOP00000027526; ENSRNOG00000020325.
DR   GeneID; 294019; -.
DR   KEGG; rno:294019; -.
DR   CTD; 51063; -.
DR   RGD; 1308276; Calhm2.
DR   eggNOG; ENOG502QVU7; Eukaryota.
DR   GeneTree; ENSGT01030000234610; -.
DR   HOGENOM; CLU_069286_1_0_1; -.
DR   InParanoid; Q5RJQ8; -.
DR   OMA; YTCALSE; -.
DR   OrthoDB; 833717at2759; -.
DR   PhylomeDB; Q5RJQ8; -.
DR   TreeFam; TF329085; -.
DR   PRO; PR:Q5RJQ8; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000020325; Expressed in spleen and 20 other tissues.
DR   Genevisible; Q5RJQ8; RN.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR029569; CALHM.
DR   InterPro; IPR029570; CALHM2.
DR   PANTHER; PTHR32261; PTHR32261; 1.
DR   PANTHER; PTHR32261:SF3; PTHR32261:SF3; 1.
DR   Pfam; PF14798; Ca_hom_mod; 1.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..323
FT                   /note="Calcium homeostasis modulator protein 2"
FT                   /id="PRO_0000186722"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  35931 MW;  B0B35F3510E65E1D CRC64;
     MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP ARNYLYGLTA
     IGVPALALFL IGVILNNHTW NLVAECQYRR AKNCSAAPTF LLLSSILGRA AVAPVTWSVI
     SLLRGEAYVC ALSEFVDPSS LTAGDEGFPP DHATEILARF PCGEGPANLS GFREEVSRRL
     KYESQLFGWL LIGVVAILVF LTKCFKHYCS PLSYRQEAYW AQYRTNEDQL FQRTAEVHSR
     VLAANNVRRF FGFVALNKDD EELVTKFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH
     KWAQGLTGNG TAPDNVEMAL LTV