VATA_THEVO
ID VATA_THEVO Reviewed; 776 AA.
AC Q97CQ0;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=V-type ATP synthase alpha chain;
DE EC=7.1.2.2;
DE AltName: Full=V-ATPase subunit A;
DE Contains:
DE RecName: Full=Tvo AtpA intein;
DE AltName: Full=Tvo VMA intein;
GN Name=atpA; OrderedLocusNames=TV0051; ORFNames=TVG0054274;
OS Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS 15438 / GSS1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT Thermoplasma volcanium.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC across the membrane. The archaeal alpha chain is a catalytic subunit.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC -!- PTM: This protein undergoes a protein self splicing that involves a
CC post-translational excision of the VDE intervening region (intein)
CC followed by peptide ligation. {ECO:0000305}.
CC -!- MISCELLANEOUS: The intein interrupts the ATP-binding site.
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000305}.
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DR EMBL; BA000011; BAB59193.1; -; Genomic_DNA.
DR RefSeq; WP_010916308.1; NC_002689.2.
DR PDB; 4O1S; X-ray; 2.70 A; A/B=234-421.
DR PDBsum; 4O1S; -.
DR AlphaFoldDB; Q97CQ0; -.
DR SMR; Q97CQ0; -.
DR STRING; 273116.14324265; -.
DR PRIDE; Q97CQ0; -.
DR EnsemblBacteria; BAB59193; BAB59193; BAB59193.
DR GeneID; 1441538; -.
DR KEGG; tvo:TVG0054274; -.
DR eggNOG; arCOG00868; Archaea.
DR HOGENOM; CLU_008162_1_1_2; -.
DR OMA; CFAKGTE; -.
DR OrthoDB; 6736at2157; -.
DR PhylomeDB; Q97CQ0; -.
DR Proteomes; UP000001017; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1140.10; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00309; ATP_synth_A_arch; 1.
DR InterPro; IPR031686; ATP-synth_a_Xtn.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR020003; ATPase_a/bsu_AS.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR024034; ATPase_F1/V1_b/a_C.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022878; V-ATPase_asu.
DR PANTHER; PTHR43607; PTHR43607; 2.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR Pfam; PF16886; ATP-synt_ab_Xtn; 1.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF50615; SSF50615; 1.
DR SUPFAM; SSF51294; SSF51294; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR01443; intein_Cterm; 1.
DR TIGRFAMs; TIGR01445; intein_Nterm; 1.
DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
DR PROSITE; PS50818; INTEIN_C_TER; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP synthesis; ATP-binding; Autocatalytic cleavage;
KW Hydrogen ion transport; Ion transport; Nucleotide-binding;
KW Protein splicing; Translocase; Transport.
FT CHAIN 1..235
FT /note="V-type ATP synthase alpha chain, 1st part"
FT /evidence="ECO:0000255"
FT /id="PRO_0000002473"
FT CHAIN 236..421
FT /note="Tvo AtpA intein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000002474"
FT CHAIN 422..776
FT /note="V-type ATP synthase alpha chain, 2nd part"
FT /evidence="ECO:0000255"
FT /id="PRO_0000002475"
FT STRAND 242..245
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 250..252
FT /evidence="ECO:0007829|PDB:4O1S"
FT HELIX 253..262
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 266..271
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 274..289
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 292..314
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 319..322
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 327..332
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 335..340
FT /evidence="ECO:0007829|PDB:4O1S"
FT TURN 341..343
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 349..353
FT /evidence="ECO:0007829|PDB:4O1S"
FT TURN 355..357
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 382..401
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 405..407
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 410..412
FT /evidence="ECO:0007829|PDB:4O1S"
FT STRAND 417..420
FT /evidence="ECO:0007829|PDB:4O1S"
SQ SEQUENCE 776 AA; 86528 MW; 50FBF72E1F5D5C50 CRC64;
MGKIVRISGP VVVAEDIENA KMYDVVKVGE MGLIGEIIRI EGNRSTIQVY EDTAGIRPDE
KVENTMRPLS VELGPGLLKS IYDGIQRPLD VIKETSGDFI ARGLNPPPLD RKKEWDFVPA
VKKNDIVYPG QVIGTVQETS LITHRIIVPD GVSGKIKSIY EGKRTVEDVV CTISTEHGDV
DVNLMTTWPV RKARRVVRKL PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGE
TPVYLADGKT IKIKDLYSSE RKKEDNIVEA GSGEEIIHLK DPIQIYSYVD GTIVRSRSRL
LYKGKSSYLV RIETIGGRSV SVTPVHKLFV LTEKGIEEVM ASNLKVGDMI AAVAESESEA
RDCGMSEECV MEAEVYTSLE ATFDRVKSIA YEKGDFDVYD LSVPEYGRNF IGGEGLLVLH
NTVIQHQLAK WSDANIVVYI GCGERGNEMT EILTTFPELK DPVSGQPLMD RTVLIANTSN
MPVAAREASI YTGITIAEYY RDMGYDVALM ADSTSRWAEA LREISGRLEE MPGEEGYPAY
LGRRISEFYE RSGRARLVSP EDRFGSITVI GAVSPPGGDI SEPVSQNTLR VTRVFWALDA
SLANRRHFPS INWLNSYSLY TEDLRHWYDE NVAKDWGSLR SQAMDILQRE SELQEVAQLV
GYDAMPEKEK SILDVARIIR EDFLQQSAFD EIDSYCSLRK QYLMLKAIME LNSYQSMAID
HGVTMDNLSS LPVREKLSRM KIVPEDQVES YYSSIIKEIH KEYTSFIGEK NAEANI
