CAHM4_MOUSE
ID CAHM4_MOUSE Reviewed; 315 AA.
AC Q8CE93;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Calcium homeostasis modulator protein 4;
DE AltName: Full=Protein FAM26D;
GN Name=Calhm4; Synonyms=Fam26d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26107.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK028763; BAC26107.1; ALT_INIT; mRNA.
DR CCDS; CCDS35878.1; -.
DR RefSeq; NP_001074634.1; NM_001081165.1.
DR AlphaFoldDB; Q8CE93; -.
DR SMR; Q8CE93; -.
DR IntAct; Q8CE93; 1.
DR STRING; 10090.ENSMUSP00000042466; -.
DR iPTMnet; Q8CE93; -.
DR PhosphoSitePlus; Q8CE93; -.
DR EPD; Q8CE93; -.
DR PaxDb; Q8CE93; -.
DR PRIDE; Q8CE93; -.
DR ProteomicsDB; 281758; -.
DR Antibodypedia; 19425; 4 antibodies from 3 providers.
DR Ensembl; ENSMUST00000048052; ENSMUSP00000042466; ENSMUSG00000039508.
DR GeneID; 270711; -.
DR KEGG; mmu:270711; -.
DR UCSC; uc007eup.1; mouse.
DR CTD; 221301; -.
DR MGI; MGI:2685489; Calhm4.
DR VEuPathDB; HostDB:ENSMUSG00000039508; -.
DR eggNOG; ENOG502RKQ2; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_3_0_1; -.
DR InParanoid; Q8CE93; -.
DR OMA; FRCPCQV; -.
DR OrthoDB; 833717at2759; -.
DR PhylomeDB; Q8CE93; -.
DR TreeFam; TF329085; -.
DR BioGRID-ORCS; 270711; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8CE93; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CE93; protein.
DR Bgee; ENSMUSG00000039508; Expressed in lip and 8 other tissues.
DR ExpressionAtlas; Q8CE93; baseline and differential.
DR Genevisible; Q8CE93; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR InterPro; IPR029569; CALHM.
DR InterPro; IPR029574; CALHM4.
DR PANTHER; PTHR32261; PTHR32261; 1.
DR PANTHER; PTHR32261:SF5; PTHR32261:SF5; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..315
FT /note="Calcium homeostasis modulator protein 4"
FT /id="PRO_0000186725"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 315 AA; 35429 MW; 546064A407A7C015 CRC64;
MSPDLNCISS SLLRSEPCIN SLIAILTVCG QQLFSSYTFS CPCQVGKNFY YGSAFLVVPA
LILLIAGYAL RGQMWTVASE YCCCSCTPPY RRSSPLERRL ACLMFFDITG RALVAPLTWL
TVTLLTGTYY ECAASEFASV DQYPMFANVT PSKREEMLAG FPCYTSAPSD VIPIRDEVAL
LHRYQSQMLG WILVVLATIA LLLSKCLARC CSPLTSLQHH YWTNHLHNER VLFEKAAEEH
SQLLIRHRIK KVFGFVPGSE DIKHIRIPSC QDWREISVPN LLCVGDTSQG PYSFLGDRVV
EENEEDRQEG IEMKP
