CAHM5_DANRE
ID CAHM5_DANRE Reviewed; 310 AA.
AC A4FUN9; A9JSX8;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Calcium homeostasis modulator protein 5;
DE AltName: Full=Protein FAM26E;
GN Name=calhm5.1; Synonyms=fam26e; ORFNames=zgc:136947;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR EMBL; CT027708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115341; AAI15342.1; -; mRNA.
DR EMBL; BC155122; AAI55123.1; -; mRNA.
DR AlphaFoldDB; A4FUN9; -.
DR SMR; A4FUN9; -.
DR STRING; 7955.ENSDARP00000099230; -.
DR PaxDb; A4FUN9; -.
DR ZFIN; ZDB-GENE-070410-4; calhm5.1.
DR eggNOG; ENOG502QPKW; Eukaryota.
DR HOGENOM; CLU_069286_2_0_1; -.
DR InParanoid; A4FUN9; -.
DR PhylomeDB; A4FUN9; -.
DR TreeFam; TF329085; -.
DR PRO; PR:A4FUN9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR InterPro; IPR029569; CALHM.
DR InterPro; IPR029572; Calhm5.
DR PANTHER; PTHR32261; PTHR32261; 1.
DR PANTHER; PTHR32261:SF8; PTHR32261:SF8; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..310
FT /note="Calcium homeostasis modulator protein 5"
FT /id="PRO_0000397603"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 99..101
FT /note="KGL -> SVF (in Ref. 2; AAI15342)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="Y -> S (in Ref. 2; AAI15342)"
FT /evidence="ECO:0000305"
FT CONFLICT 136..141
FT /note="VAVIQI -> IAVVKL (in Ref. 2; AAI15342)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="V -> I (in Ref. 2; AAI55123)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="Q -> K (in Ref. 2; AAI55123)"
FT /evidence="ECO:0000305"
FT CONFLICT 145..149
FT /note="DKGSV -> GNVSK (in Ref. 2; AAI15342)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="T -> Q (in Ref. 2; AAI15342)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="V -> I (in Ref. 2; AAI15342/AAI55123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35293 MW; A3C09E31C7D146AA CRC64;
MDSFKTVLKF FTDQKTTIGY SVMAILTIGS ERIFSMVSFQ CPCTKGQNFP YGICFLLGPA
VVLLVVGFFV STRFWRLYTG CCLNPLKLCP RGNFVGCLKG LIKVLYGACV APVMWLTVAL
LNGTFYECAV SGLDEVAVIQ IFCADKGSVC QDELHRVPCG KSTLPPEQNT ELLYMLRAQS
QILGWSVIIT AVVIALIGTC YKNCVSQVSY LQLTFWKIYM EKEREKFDAF ANDYATKLAD
RNLKSFFDNK LPEEFPFPNH KAWEEISAIY NFRKSEQHYS TLQRYVERSD RDYSPDEHPM
VEMDHGIEMV
