CAHM5_HUMAN
ID CAHM5_HUMAN Reviewed; 309 AA.
AC Q8N5C1; B2RDJ9; B3KSR3;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Calcium homeostasis modulator protein 5;
DE AltName: Full=Protein FAM26E;
GN Name=CALHM5 {ECO:0000312|HGNC:HGNC:21568}; Synonyms=C6orf188, FAM26E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR EMBL; AK094140; BAG52825.1; -; mRNA.
DR EMBL; AK315572; BAG37946.1; -; mRNA.
DR EMBL; AL121953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48226.1; -; Genomic_DNA.
DR CCDS; CCDS5108.1; -.
DR RefSeq; NP_714922.1; NM_153711.3.
DR PDB; 7D60; EM; 2.61 A; A/B/C/D/E/F/G/H/I/J/K=1-288.
DR PDB; 7D61; EM; 2.80 A; A/B/C/D/E/F/G/H/I/J/K=1-288.
DR PDB; 7D65; EM; 2.94 A; A/B/C/D/E/F/G/H/I/J/K=1-288.
DR PDBsum; 7D60; -.
DR PDBsum; 7D61; -.
DR PDBsum; 7D65; -.
DR AlphaFoldDB; Q8N5C1; -.
DR SMR; Q8N5C1; -.
DR BioGRID; 129023; 4.
DR IntAct; Q8N5C1; 1.
DR STRING; 9606.ENSP00000357588; -.
DR TCDB; 1.A.84.1.7; the calcium homeostasis modulator ca(2+) channel (calhm-c) family.
DR iPTMnet; Q8N5C1; -.
DR PhosphoSitePlus; Q8N5C1; -.
DR SwissPalm; Q8N5C1; -.
DR BioMuta; CALHM5; -.
DR DMDM; 68565211; -.
DR jPOST; Q8N5C1; -.
DR MassIVE; Q8N5C1; -.
DR MaxQB; Q8N5C1; -.
DR PaxDb; Q8N5C1; -.
DR PeptideAtlas; Q8N5C1; -.
DR PRIDE; Q8N5C1; -.
DR ProteomicsDB; 72029; -.
DR Antibodypedia; 51121; 76 antibodies from 13 providers.
DR DNASU; 254228; -.
DR Ensembl; ENST00000368599.4; ENSP00000357588.3; ENSG00000178033.6.
DR GeneID; 254228; -.
DR KEGG; hsa:254228; -.
DR MANE-Select; ENST00000368599.4; ENSP00000357588.3; NM_153711.5; NP_714922.1.
DR UCSC; uc003pwy.4; human.
DR CTD; 254228; -.
DR GeneCards; CALHM5; -.
DR HGNC; HGNC:21568; CALHM5.
DR HPA; ENSG00000178033; Low tissue specificity.
DR neXtProt; NX_Q8N5C1; -.
DR OpenTargets; ENSG00000178033; -.
DR PharmGKB; PA162387635; -.
DR VEuPathDB; HostDB:ENSG00000178033; -.
DR eggNOG; ENOG502QPKW; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_2_0_1; -.
DR InParanoid; Q8N5C1; -.
DR OMA; QHYSTIH; -.
DR OrthoDB; 817520at2759; -.
DR PhylomeDB; Q8N5C1; -.
DR TreeFam; TF329085; -.
DR PathwayCommons; Q8N5C1; -.
DR SignaLink; Q8N5C1; -.
DR BioGRID-ORCS; 254228; 8 hits in 1070 CRISPR screens.
DR GenomeRNAi; 254228; -.
DR Pharos; Q8N5C1; Tdark.
DR PRO; PR:Q8N5C1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8N5C1; protein.
DR Bgee; ENSG00000178033; Expressed in tendon of biceps brachii and 122 other tissues.
DR Genevisible; Q8N5C1; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR InterPro; IPR029569; CALHM.
DR InterPro; IPR029572; Calhm5.
DR PANTHER; PTHR32261; PTHR32261; 1.
DR PANTHER; PTHR32261:SF8; PTHR32261:SF8; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Calcium homeostasis modulator protein 5"
FT /id="PRO_0000186726"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 307
FT /note="H -> P (in Ref. 1; BAG52825)"
FT /evidence="ECO:0000305"
FT HELIX 3..7
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 10..13
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 15..37
FT /evidence="ECO:0007829|PDB:7D60"
FT STRAND 43..45
FT /evidence="ECO:0007829|PDB:7D61"
FT HELIX 47..68
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 71..77
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 80..82
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 95..106
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 109..120
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 123..130
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 138..141
FT /evidence="ECO:0007829|PDB:7D60"
FT STRAND 142..145
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 147..149
FT /evidence="ECO:0007829|PDB:7D60"
FT STRAND 150..152
FT /evidence="ECO:0007829|PDB:7D65"
FT HELIX 153..155
FT /evidence="ECO:0007829|PDB:7D60"
FT TURN 156..158
FT /evidence="ECO:0007829|PDB:7D60"
FT TURN 165..167
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 168..203
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 209..246
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 259..264
FT /evidence="ECO:0007829|PDB:7D60"
FT STRAND 273..275
FT /evidence="ECO:0007829|PDB:7D60"
FT HELIX 280..287
FT /evidence="ECO:0007829|PDB:7D60"
SQ SEQUENCE 309 AA; 35170 MW; 5FB45C91675A56C9 CRC64;
MDAFQGILKF FLNQKTVIGY SFMALLTVGS ERLFSVVAFK CPCSTENMTY GLVFLFAPAW
VLLILGFFLN NRSWRLFTGC CVNPRKIFPR GHSCRFFYVL GQITLSSLVA PVMWLSVALL
NGTFYECAMS GTRSSGLLEL ICKGKPKECW EELHKVSCGK TSMLPTVNEE LKLSLQAQSQ
ILGWCLICSA SFFSLLTTCY ARCRSKVSYL QLSFWKTYAQ KEKEQLENTF LDYANKLSER
NLKCFFENKR PDPFPMPTFA AWEAASELHS FHQSQQHYST LHRVVDNGLQ LSPEDDETTM
VLVGTAHNM
