CAHM5_MOUSE
ID CAHM5_MOUSE Reviewed; 309 AA.
AC Q8R100; Q8C3G8;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Calcium homeostasis modulator protein 5;
DE AltName: Full=Protein FAM26E;
GN Name=Calhm5; Synonyms=Fam26e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39570.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK078850; BAC37420.1; -; mRNA.
DR EMBL; AK085925; BAC39570.1; ALT_FRAME; mRNA.
DR EMBL; BC025893; AAH25893.1; -; mRNA.
DR CCDS; CCDS35879.1; -.
DR RefSeq; NP_849239.2; NM_178908.3.
DR AlphaFoldDB; Q8R100; -.
DR SMR; Q8R100; -.
DR BioGRID; 222101; 4.
DR STRING; 10090.ENSMUSP00000064462; -.
DR iPTMnet; Q8R100; -.
DR PhosphoSitePlus; Q8R100; -.
DR MaxQB; Q8R100; -.
DR PaxDb; Q8R100; -.
DR PRIDE; Q8R100; -.
DR ProteomicsDB; 273903; -.
DR Antibodypedia; 51121; 76 antibodies from 13 providers.
DR DNASU; 103511; -.
DR Ensembl; ENSMUST00000069125; ENSMUSP00000064462; ENSMUSG00000049872.
DR GeneID; 103511; -.
DR KEGG; mmu:103511; -.
DR UCSC; uc007euq.1; mouse.
DR CTD; 254228; -.
DR MGI; MGI:2143897; Calhm5.
DR VEuPathDB; HostDB:ENSMUSG00000049872; -.
DR eggNOG; ENOG502QPKW; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_2_0_1; -.
DR InParanoid; Q8R100; -.
DR OMA; QHYSTIH; -.
DR OrthoDB; 817520at2759; -.
DR PhylomeDB; Q8R100; -.
DR TreeFam; TF329085; -.
DR BioGRID-ORCS; 103511; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8R100; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8R100; protein.
DR Bgee; ENSMUSG00000049872; Expressed in lumbar dorsal root ganglion and 94 other tissues.
DR Genevisible; Q8R100; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR InterPro; IPR029569; CALHM.
DR InterPro; IPR029572; Calhm5.
DR PANTHER; PTHR32261; PTHR32261; 1.
DR PANTHER; PTHR32261:SF8; PTHR32261:SF8; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Calcium homeostasis modulator protein 5"
FT /id="PRO_0000186727"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 35285 MW; F419B4039F65B81F CRC64;
MDAFQSILKF FLNQKTAIGY SFMALLTVGS ERLFSLVAFK CPCSVENTAY GLVFLFAPAW
VLLILGFFLN NKAWRLFTGC CMNPKKIFPR RRCCRFFYVL GHIILSSLVA PVMWLSVALL
NGTFYECAMS GTRSTRLLEM ICKGKPKECW EELHKVSCGK SSMAAMESEE VRLSLQAQSQ
ILGWCLICSA SFLSLLTTCY ARCRSKVSYL QLSFWKTYAQ REKEQLENKL LECANKLSER
NLKCFFENKK PDPFPMPSFG AWEAASELHS FHQDREHYST LHKVVDDGME QTPQEEETTM
ILVGTAQSL
