ID   CAHM5_RAT               Reviewed;         309 AA.
AC   Q5FWS4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Calcium homeostasis modulator protein 5;
DE   AltName: Full=Protein FAM26E;
GN   Name=Calhm5 {ECO:0000312|RGD:1310405}; Synonyms=Fam26e;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC       {ECO:0000250|UniProtKB:Q8IU99}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR   EMBL; BC089225; AAH89225.1; -; mRNA.
DR   RefSeq; NP_001020148.1; NM_001024977.1.
DR   RefSeq; XP_017457111.1; XM_017601622.1.
DR   AlphaFoldDB; Q5FWS4; -.
DR   SMR; Q5FWS4; -.
DR   STRING; 10116.ENSRNOP00000054130; -.
DR   PaxDb; Q5FWS4; -.
DR   Ensembl; ENSRNOT00000057313; ENSRNOP00000054130; ENSRNOG00000000825.
DR   GeneID; 294431; -.
DR   KEGG; rno:294431; -.
DR   UCSC; RGD:1310405; rat.
DR   CTD; 254228; -.
DR   RGD; 1310405; Calhm5.
DR   eggNOG; ENOG502QPKW; Eukaryota.
DR   GeneTree; ENSGT01030000234610; -.
DR   HOGENOM; CLU_069286_2_0_1; -.
DR   InParanoid; Q5FWS4; -.
DR   OMA; QHYSTIH; -.
DR   OrthoDB; 817520at2759; -.
DR   PhylomeDB; Q5FWS4; -.
DR   TreeFam; TF329085; -.
DR   PRO; PR:Q5FWS4; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000825; Expressed in heart and 9 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   InterPro; IPR029569; CALHM.
DR   InterPro; IPR029572; Calhm5.
DR   PANTHER; PTHR32261; PTHR32261; 1.
DR   PANTHER; PTHR32261:SF8; PTHR32261:SF8; 1.
DR   Pfam; PF14798; Ca_hom_mod; 1.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..309
FT                   /note="Calcium homeostasis modulator protein 5"
FT                   /id="PRO_0000186728"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  35363 MW;  986FD818AB51403D CRC64;
     MDAFQSILKF FLNQKTAIGY SFMALLTVGS ERLFSLVAFK CPCSIENTAY GLVFLFAPAW
     VLLILGFFLN NKAWRLFTGC CMNPQKIFPR RRCCRFFYVL GHITLSSLVA PVMWLSVALL
     NGTFYECAMS GTRSTRLLEM ICKGKPKECW EELHKVSCGK SSMAAMDSEE VRLSLQAQSQ
     ILGWCLICSA SFFSLLTTCY ARCRSKVSYL QLSFWKTYAQ REKEQLENKL LEYANKLSER
     NLKCFFENKK PDPFPMPSFA AWEAASELHS FHQDREHYST LHKVVDDGLE QTPQEEETTM
     ILVGTAQSL