CAHM6_MOUSE
ID CAHM6_MOUSE Reviewed; 313 AA.
AC Q8C9E8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Calcium homeostasis modulator protein 6;
DE AltName: Full=Protein FAM26F;
GN Name=Calhm6; Synonyms=Fam26f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR EMBL; AK042270; BAC31209.1; -; mRNA.
DR EMBL; BC095946; AAH95946.1; -; mRNA.
DR CCDS; CCDS23775.1; -.
DR RefSeq; NP_780658.2; NM_175449.4.
DR AlphaFoldDB; Q8C9E8; -.
DR SMR; Q8C9E8; -.
DR STRING; 10090.ENSMUSP00000051575; -.
DR iPTMnet; Q8C9E8; -.
DR PhosphoSitePlus; Q8C9E8; -.
DR SwissPalm; Q8C9E8; -.
DR EPD; Q8C9E8; -.
DR MaxQB; Q8C9E8; -.
DR PaxDb; Q8C9E8; -.
DR PRIDE; Q8C9E8; -.
DR ProteomicsDB; 265426; -.
DR Antibodypedia; 19421; 37 antibodies from 17 providers.
DR Ensembl; ENSMUST00000062784; ENSMUSP00000051575; ENSMUSG00000046031.
DR GeneID; 215900; -.
DR KEGG; mmu:215900; -.
DR UCSC; uc007eur.2; mouse.
DR CTD; 441168; -.
DR MGI; MGI:2443082; Calhm6.
DR VEuPathDB; HostDB:ENSMUSG00000046031; -.
DR eggNOG; ENOG502QSG7; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_2_0_1; -.
DR InParanoid; Q8C9E8; -.
DR OMA; AVVFQCP; -.
DR OrthoDB; 1039097at2759; -.
DR PhylomeDB; Q8C9E8; -.
DR TreeFam; TF329085; -.
DR BioGRID-ORCS; 215900; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8C9E8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8C9E8; protein.
DR Bgee; ENSMUSG00000046031; Expressed in peripheral lymph node and 76 other tissues.
DR Genevisible; Q8C9E8; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR InterPro; IPR029569; CALHM.
DR InterPro; IPR029573; CALHM6.
DR PANTHER; PTHR32261; PTHR32261; 1.
DR PANTHER; PTHR32261:SF4; PTHR32261:SF4; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..313
FT /note="Calcium homeostasis modulator protein 6"
FT /id="PRO_0000283782"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 313 AA; 34956 MW; 30CAE1E07ADD8825 CRC64;
MEKFKAVLDL QRKHRNALGY SLVTLLTAGG EKIFSSVVFQ CPCTATWNLP YGLVFLLVPA
LALFLLGYAL SARTWRLLTG CCSRSARFSS GLRSAFVCAQ LSMTAAFAPL TWVAVALLEG
SFYQCAVSGS ARLAPYLCKG RDPNCNATLP QAPCNKQKVE MQEILSQLKA QSQVFGWILI
AAVIILLLLV KSVTRCFSPV SYLQLKFWEI YWEKEKQILQ NQAAENATQL AEENVRCFFE
CSKPKECNTP SSKDWQEISA LYTFNPKNQF YSMLHKYVSR EEMSGSVRSV EGDAVIPALG
FVDDMSMTNT HEL
