ID   CAHM6_RAT               Reviewed;         315 AA.
AC   Q561R8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Calcium homeostasis modulator protein 6;
DE   AltName: Full=Protein FAM26F;
GN   Name=Calhm6 {ECO:0000312|RGD:1304835}; Synonyms=Fam26f;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC       {ECO:0000250|UniProtKB:Q8IU99}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR   EMBL; BC093379; AAH93379.1; -; mRNA.
DR   RefSeq; NP_001020147.1; NM_001024976.1.
DR   AlphaFoldDB; Q561R8; -.
DR   SMR; Q561R8; -.
DR   STRING; 10116.ENSRNOP00000054134; -.
DR   PaxDb; Q561R8; -.
DR   PRIDE; Q561R8; -.
DR   Ensembl; ENSRNOT00000057317; ENSRNOP00000054134; ENSRNOG00000037757.
DR   GeneID; 294430; -.
DR   KEGG; rno:294430; -.
DR   UCSC; RGD:1304835; rat.
DR   CTD; 441168; -.
DR   RGD; 1304835; Calhm6.
DR   eggNOG; ENOG502QSG7; Eukaryota.
DR   GeneTree; ENSGT01030000234610; -.
DR   HOGENOM; CLU_069286_2_0_1; -.
DR   InParanoid; Q561R8; -.
DR   OMA; AVVFQCP; -.
DR   OrthoDB; 1039097at2759; -.
DR   PhylomeDB; Q561R8; -.
DR   TreeFam; TF329085; -.
DR   PRO; PR:Q561R8; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000037757; Expressed in spleen and 14 other tissues.
DR   Genevisible; Q561R8; RN.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   InterPro; IPR029569; CALHM.
DR   InterPro; IPR029573; CALHM6.
DR   PANTHER; PTHR32261; PTHR32261; 1.
DR   PANTHER; PTHR32261:SF4; PTHR32261:SF4; 1.
DR   Pfam; PF14798; Ca_hom_mod; 1.
PE   1: Evidence at protein level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..315
FT                   /note="Calcium homeostasis modulator protein 6"
FT                   /id="PRO_0000283783"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   315 AA;  34730 MW;  D7D0E73F4EF9BDCB CRC64;
     MEKFKAVLDL QIKHRSALGY GLVTLLTAGG EKIFSTVVFQ CPCTATLNLT YGLVFLLVPA
     LALFLLGYAL SARTWRLLTG CCSRSASTRS SSGLRSTLVC AQVSAVAALA PLTWVAVALL
     GGSFYQCAVS GSTRLASYLC KDRNHSCIAK LPQVPCNKQE AEMQEILSQL KAQSQVLGWV
     LIAAVIFLLL VFKCVSRCFS PVSYLQLKFW EIYLEKEKQI LQSQAAEHAT QLARENIRSF
     FECSKPKECN TPSRKDWQQI SALYTFNSKN QFYSMLHKYV SRKEVSSSLH SVEGDVVVPV
     LGFVDDAAMA NTHGV