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VATC2_RAT
ID   VATC2_RAT               Reviewed;         425 AA.
AC   Q6AYE4; Q53B80;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=V-type proton ATPase subunit C 2;
DE            Short=V-ATPase subunit C 2;
DE   AltName: Full=Vacuolar proton pump subunit C 2;
GN   Name=Atp6v1c2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=16283434; DOI=10.1007/s11373-005-9020-3;
RA   Feng N.-H., Lin H.-I., Wang J.-S., Chou S.-T., Ma H.-K., Rooney S.A.,
RA   Lu J.-F.;
RT   "Differential expression of a V-type ATPase C subunit gene, Atp6v1c2,
RT   during culture of rat lung type II pneumocytes.";
RL   J. Biomed. Sci. 12:899-911(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase),
CC       a multisubunit enzyme composed of a peripheral complex (V1) that
CC       hydrolyzes ATP and a membrane integral complex (V0) that translocates
CC       protons. V-ATPase is responsible for acidifying and maintaining the pH
CC       of intracellular compartments and in some cell types, is targeted to
CC       the plasma membrane, where it is responsible for acidifying the
CC       extracellular environment (By similarity). Subunit C is necessary for
CC       the assembly of the catalytic sector of the enzyme and is likely to
CC       have a specific function in its catalytic activity (By similarity).
CC       {ECO:0000250|UniProtKB:P31412, ECO:0000250|UniProtKB:Q5FVI6}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme made up of two
CC       complexes: the ATP-hydrolytic V1 complex and the proton translocation
CC       V0 complex. The V1 complex consists of three catalytic AB heterodimers
CC       that form a heterohexamer, three peripheral stalks each consisting of
CC       EG heterodimers, one central rotor including subunits D and F, and the
CC       regulatory subunits C and H. The proton translocation complex V0
CC       consists of the proton transport subunit a, a ring of proteolipid
CC       subunits c9c'', rotary subunit d, subunits e and f, and the accessory
CC       subunits ATP6AP1/Ac45 and ATP6AP2/PRR. {ECO:0000250|UniProtKB:Q5FVI6}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=C2-a;
CC         IsoId=Q6AYE4-1; Sequence=Displayed;
CC       Name=2; Synonyms=C2-b;
CC         IsoId=Q6AYE4-2; Sequence=VSP_024886;
CC   -!- TISSUE SPECIFICITY: Lung, kidney and testis. Expressed in both
CC       bronchiolar and alveolar lung epithelial cells. Isoform 1 is
CC       predominantly expressed in the lung while isoform 2 is strongly
CC       expressed in the kidney and testis. {ECO:0000269|PubMed:16283434}.
CC   -!- SIMILARITY: Belongs to the V-ATPase C subunit family. {ECO:0000305}.
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DR   EMBL; AY594319; AAT44904.1; -; mRNA.
DR   EMBL; BC079083; AAH79083.1; -; mRNA.
DR   RefSeq; NP_001014221.1; NM_001014199.1. [Q6AYE4-1]
DR   AlphaFoldDB; Q6AYE4; -.
DR   SMR; Q6AYE4; -.
DR   STRING; 10116.ENSRNOP00000066981; -.
DR   PRIDE; Q6AYE4; -.
DR   Ensembl; ENSRNOT00000071977; ENSRNOP00000066981; ENSRNOG00000050553. [Q6AYE4-1]
DR   Ensembl; ENSRNOT00000099858; ENSRNOP00000093823; ENSRNOG00000050553. [Q6AYE4-2]
DR   GeneID; 362802; -.
DR   KEGG; rno:362802; -.
DR   CTD; 245973; -.
DR   RGD; 1359430; Atp6v1c2.
DR   GeneTree; ENSGT00390000004263; -.
DR   InParanoid; Q6AYE4; -.
DR   OrthoDB; 1016088at2759; -.
DR   PhylomeDB; Q6AYE4; -.
DR   Reactome; R-RNO-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-RNO-77387; Insulin receptor recycling.
DR   Reactome; R-RNO-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-RNO-9639288; Amino acids regulate mTORC1.
DR   Reactome; R-RNO-983712; Ion channel transport.
DR   PRO; PR:Q6AYE4; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; ISO:RGD.
DR   GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISO:RGD.
DR   CDD; cd14785; V-ATPase_C; 1.
DR   InterPro; IPR004907; ATPase_V1-cplx_csu.
DR   InterPro; IPR036132; Vac_ATP_synth_c_sf.
DR   PANTHER; PTHR10137; PTHR10137; 1.
DR   Pfam; PF03223; V-ATPase_C; 1.
DR   SUPFAM; SSF118203; SSF118203; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hydrogen ion transport; Ion transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..425
FT                   /note="V-type proton ATPase subunit C 2"
FT                   /id="PRO_0000285671"
FT   REGION          295..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         276..319
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16283434"
FT                   /id="VSP_024886"
FT   CONFLICT        49
FT                   /note="S -> P (in Ref. 1; AAT44904)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   425 AA;  48243 MW;  698606392087372D CRC64;
     MSEFWLISAP GDKENLQALE RMNSVTSKSN LSHNTKFAIP DFKVGTLDSL VGLSDELGKL
     DTFAESLIKR MAQSVVEVME DSKGKVHENL LANGVDLTSF VTHFEWDMAK YPAKQPLVSV
     VDTLAKQLAQ IETDLKSRTA AYSVLKANLE NLEKKSTGNL FTRTLSDIVS KEDFVLDSEY
     LITLLVIVPK SSYVQWQKTY ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA
     KENKFIVREF YYDEKEIKRE REEMTRLLSD KKQQYQTSCV ALKKGSATYR DHKVKVTPLG
     NPTRPTAGQN DRESEGEGEG PLLRWLKVNF SEAFIAWIHI KALRVFVESV LRYGLPVNFQ
     AVLLQPHKKS ATKRLREVLN SVFRHLDEVA AASILDASVE IPGLQLSNQD YFPYVYFHID
     LSLLD
 
 
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