VATC_ARATH
ID VATC_ARATH Reviewed; 375 AA.
AC Q9SDS7;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=V-type proton ATPase subunit C;
DE Short=V-ATPase subunit C;
DE AltName: Full=Vacuolar H(+)-ATPase subunit C;
DE AltName: Full=Vacuolar proton pump subunit C;
GN Name=VHA-C; Synonyms=DET3, VATC; OrderedLocusNames=At1g12840;
GN ORFNames=F13K23.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617574; DOI=10.1101/gad.13.24.3259;
RA Schumacher K., Vafeados D., McCarthy M., Sze H., Wilkins T., Chory J.;
RT "The Arabidopsis det3 mutant reveals a central role for the vacuolar H(+)-
RT ATPase in plant growth and development.";
RL Genes Dev. 13:3259-3270(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11950611; DOI=10.1016/s1360-1385(02)02240-9;
RA Sze H., Schumacher K., Mueller M.L., Padmanaban S., Taiz L.;
RT "A simple nomenclature for a complex proton pump: VHA genes encode the
RT vacuolar H(+)-ATPase.";
RL Trends Plant Sci. 7:157-161(2002).
RN [6]
RP PHOSPHORYLATION BY WNK8.
RX PubMed=16427632; DOI=10.1016/j.febslet.2006.01.018;
RA Hong-Hermesdorf A., Bruex A., Grueber A., Grueber G., Schumacher K.;
RT "A WNK kinase binds and phosphorylates V-ATPase subunit C.";
RL FEBS Lett. 580:932-939(2006).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=17151019; DOI=10.1074/mcp.m600250-mcp200;
RA Jaquinod M., Villiers F., Kieffer-Jaquinod S., Hugouvieux V., Bruley C.,
RA Garin J., Bourguignon J.;
RT "A proteomics dissection of Arabidopsis thaliana vacuoles isolated from
RT cell culture.";
RL Mol. Cell. Proteomics 6:394-412(2007).
CC -!- FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase.
CC Subunit C is necessary for the assembly of the catalytic sector of the
CC enzyme and is likely to have a specific function in its catalytic
CC activity. V-ATPase is responsible for acidifying a variety of
CC intracellular compartments in eukaryotic cells.
CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC catalytic V1 complex (components A to H) attached to an integral
CC membrane V0 proton pore complex (components: a, c, c'', d and e).
CC -!- INTERACTION:
CC Q9SDS7; Q944Q0: WNK8; NbExp=4; IntAct=EBI-1794418, EBI-4441446;
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:17151019};
CC Peripheral membrane protein {ECO:0000305}.
CC -!- PTM: Phosphorylated on Ser/Thr residues by WNK8.
CC {ECO:0000269|PubMed:16427632}.
CC -!- SIMILARITY: Belongs to the V-ATPase C subunit family. {ECO:0000305}.
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DR EMBL; AF208261; AAF20146.1; -; mRNA.
DR EMBL; AC012187; AAF78489.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28936.1; -; Genomic_DNA.
DR EMBL; AF334725; AAG50103.1; -; mRNA.
DR EMBL; AY059872; AAL24354.1; -; mRNA.
DR EMBL; AY093334; AAM13333.1; -; mRNA.
DR PIR; T52300; T52300.
DR RefSeq; NP_563916.1; NM_101154.4.
DR AlphaFoldDB; Q9SDS7; -.
DR SMR; Q9SDS7; -.
DR BioGRID; 23080; 14.
DR IntAct; Q9SDS7; 8.
DR MINT; Q9SDS7; -.
DR STRING; 3702.AT1G12840.1; -.
DR TCDB; 3.A.2.2.5; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR iPTMnet; Q9SDS7; -.
DR PaxDb; Q9SDS7; -.
DR PRIDE; Q9SDS7; -.
DR ProteomicsDB; 228577; -.
DR EnsemblPlants; AT1G12840.1; AT1G12840.1; AT1G12840.
DR GeneID; 837840; -.
DR Gramene; AT1G12840.1; AT1G12840.1; AT1G12840.
DR KEGG; ath:AT1G12840; -.
DR Araport; AT1G12840; -.
DR TAIR; locus:2010386; AT1G12840.
DR eggNOG; KOG2909; Eukaryota.
DR HOGENOM; CLU_017554_3_0_1; -.
DR InParanoid; Q9SDS7; -.
DR OMA; GEYWLIS; -.
DR OrthoDB; 1016088at2759; -.
DR PhylomeDB; Q9SDS7; -.
DR PRO; PR:Q9SDS7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SDS7; baseline and differential.
DR Genevisible; Q9SDS7; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005774; C:vacuolar membrane; HDA:TAIR.
DR GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IDA:TAIR.
DR GO; GO:0005773; C:vacuole; HDA:TAIR.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0009826; P:unidimensional cell growth; IMP:TAIR.
DR CDD; cd14785; V-ATPase_C; 1.
DR InterPro; IPR004907; ATPase_V1-cplx_csu.
DR InterPro; IPR036132; Vac_ATP_synth_c_sf.
DR PANTHER; PTHR10137; PTHR10137; 1.
DR Pfam; PF03223; V-ATPase_C; 1.
DR SUPFAM; SSF118203; SSF118203; 1.
PE 1: Evidence at protein level;
KW Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Transport; Vacuole.
FT CHAIN 1..375
FT /note="V-type proton ATPase subunit C"
FT /id="PRO_0000209355"
SQ SEQUENCE 375 AA; 42619 MW; A50F11D168F31C97 CRC64;
MTSRYWVVSL PVKDSASSLW NRLQEQISKH SFDTPVYRFN IPNLRVGTLD SLLALGDDLL
KSNSFVEGVS QKIRRQIEEL ERISGVESNA LTVDGVPVDS YLTRFVWDEA KYPTMSPLKE
VVDNIQSQVA KIEDDLKVRV AEYNNIRGQL NAINRKQSGS LAVRDLSNLV KPEDIVESEH
LVTLLAVVPK YSQKDWLACY ETLTDYVVPR SSKKLFEDNE YALYTVTLFT RVADNFRIAA
REKGFQVRDF EQSVEAQETR KQELAKLVQD QESLRSSLLQ WCYTSYGEVF SSWMHFCAVR
TFAESIMRYG LPPAFLACVL SPAVKSEKKV RSILERLCDS TNSLYWKSEE DAGAMAGLAG
DSETHPYVSF TINLA
