ID   VATC_DICDI              Reviewed;         368 AA.
AC   P54648; Q54PH0;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=V-type proton ATPase subunit C;
DE            Short=V-ATPase subunit C;
DE   AltName: Full=Vacuolar proton pump subunit C;
GN   Name=vatC; ORFNames=DDB_G0284473;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RA   Gerisch G., Westphal M.;
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase.
CC       Subunit C is necessary for the assembly of the catalytic sector of the
CC       enzyme and is likely to have a specific function in its catalytic
CC       activity. V-ATPase is responsible for acidifying a variety of
CC       intracellular compartments in eukaryotic cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC       catalytic V1 complex (components A to H) attached to an integral
CC       membrane V0 proton pore complex (components: a, c, c', c'' and d).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the V-ATPase C subunit family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L41839; AAA65499.1; -; mRNA.
DR   EMBL; AAFI02000066; EAL65163.1; -; Genomic_DNA.
DR   RefSeq; XP_638562.1; XM_633470.1.
DR   AlphaFoldDB; P54648; -.
DR   SMR; P54648; -.
DR   STRING; 44689.DDB0191419; -.
DR   PaxDb; P54648; -.
DR   PRIDE; P54648; -.
DR   ABCD; P54648; 1 sequenced antibody.
DR   EnsemblProtists; EAL65163; EAL65163; DDB_G0284473.
DR   GeneID; 8624654; -.
DR   KEGG; ddi:DDB_G0284473; -.
DR   dictyBase; DDB_G0284473; vatC.
DR   eggNOG; KOG2909; Eukaryota.
DR   HOGENOM; CLU_017554_3_0_1; -.
DR   InParanoid; P54648; -.
DR   OMA; GEYWLIS; -.
DR   PhylomeDB; P54648; -.
DR   Reactome; R-DDI-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-DDI-77387; Insulin receptor recycling.
DR   Reactome; R-DDI-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:P54648; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0031164; C:contractile vacuolar membrane; TAS:dictyBase.
DR   GO; GO:0005769; C:early endosome; IDA:dictyBase.
DR   GO; GO:0005764; C:lysosome; IDA:dictyBase.
DR   GO; GO:0140220; C:pathogen-containing vacuole; HDA:dictyBase.
DR   GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   CDD; cd14785; V-ATPase_C; 1.
DR   InterPro; IPR004907; ATPase_V1-cplx_csu.
DR   InterPro; IPR036132; Vac_ATP_synth_c_sf.
DR   PANTHER; PTHR10137; PTHR10137; 1.
DR   Pfam; PF03223; V-ATPase_C; 1.
DR   SUPFAM; SSF118203; SSF118203; 1.
PE   2: Evidence at transcript level;
KW   Hydrogen ion transport; Ion transport; Reference proteome; Transport.
FT   CHAIN           1..368
FT                   /note="V-type proton ATPase subunit C"
FT                   /id="PRO_0000209352"
SQ   SEQUENCE   368 AA;  42287 MW;  21168750918877CA CRC64;
     MSETQEFWLI SAPNLPGADI FDQVNQKTAK ENSLSENKKF NTPALRVGTL NSLITLNDEL
     QKIDTIVEST TKKIARQLVD LVGTKPGKDK SLSINGHTIP QYLQQFAWDD AKYNLKLSLQ
     EIVEKISSAV SKIDDDLKIK SSEYSTLSSS VASEERKASG NLQVRTLNDL ITADNIVQTD
     YFTTAFVVIP KQSEKEFLAC YETISDFVLG RSAKRVAQDN DYFLYSVILF KKFYENFKTK
     IIEKKWVVRD FKLEDNKPTQ ERSKLTEDKK NCRTSLIRWC RLNFPEAFMA WVHLKVVRVF
     VESVLRFGIP FNFQAILMKP QKGADKKVRD ILFDQFKYLG SAHISGKNET DDSEKFYPYI
     SVSVNWEN