VATD_DICDI
ID VATD_DICDI Reviewed; 257 AA.
AC Q86A77; Q555Z1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=V-type proton ATPase subunit D;
DE Short=V-ATPase subunit D;
DE AltName: Full=Vacuolar proton pump subunit D;
GN Name=atp6v1d; ORFNames=DDB_G0274331;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase.
CC Vacuolar ATPase is responsible for acidifying a variety of
CC intracellular compartments in eukaryotic cells, thus providing most of
CC the energy required for transport processes in the vacuolar system (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC catalytic V1 complex (components A to H) attached to an integral
CC membrane V0 proton pore complex (components: a, c, c', c'' and d).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the V-ATPase D subunit family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70058.1; -; Genomic_DNA.
DR RefSeq; XP_643919.1; XM_638827.1.
DR AlphaFoldDB; Q86A77; -.
DR SMR; Q86A77; -.
DR STRING; 44689.DDB0235141; -.
DR PaxDb; Q86A77; -.
DR EnsemblProtists; EAL70058; EAL70058; DDB_G0274331.
DR GeneID; 8619346; -.
DR KEGG; ddi:DDB_G0274331; -.
DR dictyBase; DDB_G0274331; -.
DR eggNOG; KOG1647; Eukaryota.
DR HOGENOM; CLU_069688_0_0_1; -.
DR InParanoid; Q86A77; -.
DR OMA; SKNIMGV; -.
DR PhylomeDB; Q86A77; -.
DR Reactome; R-DDI-1222556; ROS and RNS production in phagocytes.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-77387; Insulin receptor recycling.
DR Reactome; R-DDI-917977; Transferrin endocytosis and recycling.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q86A77; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0033176; C:proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; ISS:UniProtKB.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; ISS:UniProtKB.
DR InterPro; IPR002699; V_ATPase_D.
DR PANTHER; PTHR11671; PTHR11671; 1.
DR Pfam; PF01813; ATP-synt_D; 1.
DR TIGRFAMs; TIGR00309; V_ATPase_subD; 1.
PE 1: Evidence at protein level;
KW Hydrogen ion transport; Ion transport; Reference proteome; Transport.
FT CHAIN 1..257
FT /note="V-type proton ATPase subunit D"
FT /id="PRO_0000327814"
FT REGION 211..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 28610 MW; 4738B1BAC936AC6D CRC64;
MSGKNRLNIF PTRMALTVMK TKLKGAVTGH SLLKKKSDAL TIRFRRILAN IVENKQLMGT
TMRDASFSLA AAKYAAGEFS NSVIENVSNP TIAVKMTTEN VAGVHLPTFE KISEGVVSNS
QELTGLSKGG QQINKSRESH IKAVEALIAL ASLQTAFITL DEVIKITNRR VNAIEYVVKP
KLENTISYII TELDESEREE FYRLKKVQGK KKKDLKAKEA QKEENSANKT IMEPASVHKV
RSLIDDEPED AELLYED
