VATD_SUBDO
ID VATD_SUBDO Reviewed; 250 AA.
AC P57747;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2001, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=V-type proton ATPase subunit D;
DE Short=V-ATPase subunit D;
DE AltName: Full=Vacuolar proton pump subunit D;
GN Name=VATPD;
OS Suberites domuncula (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Suberitida;
OC Suberitidae; Suberites.
OX NCBI_TaxID=55567;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mueller W.E.G., Wiens M.;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase),
CC a multisubunit enzyme composed of a peripheral complex (V1) that
CC hydrolyzes ATP and a membrane integral complex (V0) that translocates
CC protons (By similarity). V-ATPase is responsible for acidifying and
CC maintaining the pH of intracellular compartments and in some cell
CC types, is targeted to the plasma membrane, where it is responsible for
CC acidifying the extracellular environment (By similarity).
CC {ECO:0000250|UniProtKB:P39942, ECO:0000250|UniProtKB:Q9Y5K8}.
CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme made up of two
CC complexes: the ATP-hydrolytic V1 complex and the proton translocation
CC V0 complex (By similarity). The V1 complex consists of three catalytic
CC AB heterodimers that form a heterohexamer, three peripheral stalks each
CC consisting of EG heterodimers, one central rotor including subunits D
CC and F, and the regulatory subunits C and H (By similarity). The proton
CC translocation complex V0 consists of the proton transport subunit a, a
CC ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f,
CC and two accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By
CC similarity). {ECO:0000250|UniProtKB:Q9Y5K8}.
CC -!- SIMILARITY: Belongs to the V-ATPase D subunit family. {ECO:0000305}.
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DR EMBL; AJ297976; CAC17412.1; -; mRNA.
DR AlphaFoldDB; P57747; -.
DR SMR; P57747; -.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR HAMAP; MF_00271; ATP_synth_D_arch; 1.
DR InterPro; IPR002699; V_ATPase_D.
DR PANTHER; PTHR11671; PTHR11671; 1.
DR Pfam; PF01813; ATP-synt_D; 1.
DR TIGRFAMs; TIGR00309; V_ATPase_subD; 1.
PE 2: Evidence at transcript level;
KW Hydrogen ion transport; Ion transport; Transport.
FT CHAIN 1..250
FT /note="V-type proton ATPase subunit D"
FT /id="PRO_0000144239"
SQ SEQUENCE 250 AA; 28374 MW; B5533BA406B70DED CRC64;
MSGKDRINVF PSRMALTLMK ARLKGAQKGH SLLKRKADAL TLRFRQILGK IIETKTLMGE
VMKEATFSLA EAKFVAGDFS EMVLQNVDKA KIRLHTKKDN VAGVTLPVFE TYSDGSDTYE
LTGLSRGGQL VSKCKEVFGK AVRLLVELAS LQTAFVTLDE VIKVTNRRVN AIEHVIIPKI
QRTLSYISIE LDEREREEFY RLKKIQEKKK KQKAIKEKET EIRIARQKNK KSAAPVKTIF
ETGNDDDLLF