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VATD_SUBDO
ID   VATD_SUBDO              Reviewed;         250 AA.
AC   P57747;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2001, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=V-type proton ATPase subunit D;
DE            Short=V-ATPase subunit D;
DE   AltName: Full=Vacuolar proton pump subunit D;
GN   Name=VATPD;
OS   Suberites domuncula (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Suberitida;
OC   Suberitidae; Suberites.
OX   NCBI_TaxID=55567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mueller W.E.G., Wiens M.;
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase),
CC       a multisubunit enzyme composed of a peripheral complex (V1) that
CC       hydrolyzes ATP and a membrane integral complex (V0) that translocates
CC       protons (By similarity). V-ATPase is responsible for acidifying and
CC       maintaining the pH of intracellular compartments and in some cell
CC       types, is targeted to the plasma membrane, where it is responsible for
CC       acidifying the extracellular environment (By similarity).
CC       {ECO:0000250|UniProtKB:P39942, ECO:0000250|UniProtKB:Q9Y5K8}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme made up of two
CC       complexes: the ATP-hydrolytic V1 complex and the proton translocation
CC       V0 complex (By similarity). The V1 complex consists of three catalytic
CC       AB heterodimers that form a heterohexamer, three peripheral stalks each
CC       consisting of EG heterodimers, one central rotor including subunits D
CC       and F, and the regulatory subunits C and H (By similarity). The proton
CC       translocation complex V0 consists of the proton transport subunit a, a
CC       ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f,
CC       and two accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By
CC       similarity). {ECO:0000250|UniProtKB:Q9Y5K8}.
CC   -!- SIMILARITY: Belongs to the V-ATPase D subunit family. {ECO:0000305}.
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DR   EMBL; AJ297976; CAC17412.1; -; mRNA.
DR   AlphaFoldDB; P57747; -.
DR   SMR; P57747; -.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   HAMAP; MF_00271; ATP_synth_D_arch; 1.
DR   InterPro; IPR002699; V_ATPase_D.
DR   PANTHER; PTHR11671; PTHR11671; 1.
DR   Pfam; PF01813; ATP-synt_D; 1.
DR   TIGRFAMs; TIGR00309; V_ATPase_subD; 1.
PE   2: Evidence at transcript level;
KW   Hydrogen ion transport; Ion transport; Transport.
FT   CHAIN           1..250
FT                   /note="V-type proton ATPase subunit D"
FT                   /id="PRO_0000144239"
SQ   SEQUENCE   250 AA;  28374 MW;  B5533BA406B70DED CRC64;
     MSGKDRINVF PSRMALTLMK ARLKGAQKGH SLLKRKADAL TLRFRQILGK IIETKTLMGE
     VMKEATFSLA EAKFVAGDFS EMVLQNVDKA KIRLHTKKDN VAGVTLPVFE TYSDGSDTYE
     LTGLSRGGQL VSKCKEVFGK AVRLLVELAS LQTAFVTLDE VIKVTNRRVN AIEHVIIPKI
     QRTLSYISIE LDEREREEFY RLKKIQEKKK KQKAIKEKET EIRIARQKNK KSAAPVKTIF
     ETGNDDDLLF
 
 
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