ID   CAH_METJA               Reviewed;         159 AA.
AC   Q57752;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Probable carbonic anhydrase {ECO:0000305};
DE            Short=CA;
DE            EC=4.2.1.1 {ECO:0000250|UniProtKB:P40881};
GN   OrderedLocusNames=MJ0304;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Probably reversibly hydrates carbon dioxide. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17544; EC=4.2.1.1;
CC         Evidence={ECO:0000250|UniProtKB:P40881};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:P40881};
CC   -!- SIMILARITY: Belongs to the gamma-class carbonic anhydrase family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB98291.1; -; Genomic_DNA.
DR   PIR; A64338; A64338.
DR   RefSeq; WP_010869802.1; NC_000909.1.
DR   AlphaFoldDB; Q57752; -.
DR   SMR; Q57752; -.
DR   STRING; 243232.MJ_0304; -.
DR   EnsemblBacteria; AAB98291; AAB98291; MJ_0304.
DR   GeneID; 1451159; -.
DR   KEGG; mja:MJ_0304; -.
DR   eggNOG; arCOG01849; Archaea.
DR   HOGENOM; CLU_064827_4_1_2; -.
DR   InParanoid; Q57752; -.
DR   OMA; YVTIGHN; -.
DR   OrthoDB; 84330at2157; -.
DR   PhylomeDB; Q57752; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00132; Hexapep; 2.
DR   SUPFAM; SSF51161; SSF51161; 1.
PE   3: Inferred from homology;
KW   Lyase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..159
FT                   /note="Probable carbonic anhydrase"
FT                   /id="PRO_0000077472"
FT   BINDING         33..35
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P40881"
FT   BINDING         48..49
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P40881"
FT   BINDING         54
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P40881"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P40881"
FT   BINDING         76
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P40881"
SQ   SEQUENCE   159 AA;  17174 MW;  8EBE072E411BCC94 CRC64;
     MISKNVRIAK GAVIVGDVTI GDYSSVWYNA VIRGDVDKII IGNYSNIQDC CVVHCSKGYP
     TIIGDYVSIG HGAVIHGCRI EDNVLVGMNA TILNGAKIGE NCIIGANALV TQNKEIPPNS
     LVLGVPGRVV RELTEEEIKS IKENALRYVK LSETLESYK