ID   VATF_DICDI              Reviewed;         120 AA.
AC   Q55AH5; Q86HF9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=V-type proton ATPase subunit F;
DE            Short=V-ATPase subunit F;
DE   AltName: Full=Vacuolar proton pump subunit F;
GN   Name=vatF; ORFNames=DDB_G0271882;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase
CC       essential for assembly or catalytic function. V-ATPase is responsible
CC       for acidifying a variety of intracellular compartments in eukaryotic
CC       cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC       catalytic V1 complex (components A to H) attached to an integral
CC       membrane V0 proton pore complex (components: a, c, c', c'' and d).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the V-ATPase F subunit family. {ECO:0000305}.
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DR   EMBL; AAFI02000007; EAL71520.1; -; Genomic_DNA.
DR   RefSeq; XP_645434.1; XM_640342.1.
DR   AlphaFoldDB; Q55AH5; -.
DR   SMR; Q55AH5; -.
DR   STRING; 44689.DDB0305002; -.
DR   PaxDb; Q55AH5; -.
DR   EnsemblProtists; EAL71520; EAL71520; DDB_G0271882.
DR   GeneID; 8618174; -.
DR   KEGG; ddi:DDB_G0271882; -.
DR   dictyBase; DDB_G0271882; vatF.
DR   eggNOG; KOG3432; Eukaryota.
DR   HOGENOM; CLU_135754_0_0_1; -.
DR   InParanoid; Q55AH5; -.
DR   OMA; YTNAFPA; -.
DR   PhylomeDB; Q55AH5; -.
DR   Reactome; R-DDI-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-DDI-77387; Insulin receptor recycling.
DR   Reactome; R-DDI-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q55AH5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031164; C:contractile vacuolar membrane; TAS:dictyBase.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   Gene3D; 3.40.50.10580; -; 1.
DR   InterPro; IPR008218; ATPase_V1-cplx_f_g_su.
DR   InterPro; IPR005772; ATPase_V1-cplx_fsu_euk.
DR   InterPro; IPR036906; ATPase_V1_fsu_sf.
DR   Pfam; PF01990; ATP-synt_F; 1.
DR   PIRSF; PIRSF015945; ATPase_V1_F_euk; 1.
DR   SUPFAM; SSF159468; SSF159468; 1.
DR   TIGRFAMs; TIGR01101; V_ATP_synt_F; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport; Ion transport; Reference proteome; Transport.
FT   CHAIN           1..120
FT                   /note="V-type proton ATPase subunit F"
FT                   /id="PRO_0000328536"
SQ   SEQUENCE   120 AA;  13345 MW;  54835E0C8DD38D6A CRC64;
     MATKSLSETA LVAVIGDEDV VTGFLLAGVG QKDKKKNENF LVVDSKTSQA KIETAFKSFT
     TRNDIAIIMI TQKVADEIRY LIDEYHQVIP TILEIPSKDH PYDPKKDSVM LKVKKMTGSD