ID   CAI19_CONGE             Reviewed;          68 AA.
AC   X5IFZ1;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 1.
DT   03-AUG-2022, entry version 11.
DE   RecName: Full=Conotoxin G1.9 {ECO:0000303|PubMed:34062129};
DE   Flags: Precursor;
OS   Conus geographus (Geography cone) (Nubecula geographus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Gastridium.
OX   NCBI_TaxID=6491;
RN   [1] {ECO:0000312|EMBL:BAO65578.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=24662800; DOI=10.1038/ncomms4521;
RA   Dutertre S., Jin A.-H., Vetter I., Hamilton B., Sunagar K., Lavergne V.,
RA   Dutertre V., Fry B.G., Antunes A., Venter D.J., Alewood P.F., Lewis R.J.;
RT   "Evolution of separate predation- and defence-evoked venoms in carnivorous
RT   cone snails.";
RL   Nat. Commun. 5:3521-3521(2014).
RN   [2]
RP   SYNTHESIS OF 45-68 AS GLOBULAR AND RIBBON ISOMER, AND FUNCTION.
RX   PubMed=34062129; DOI=10.1016/j.bcp.2021.114638;
RA   Tae H.S., Gao B., Jin A.H., Alewood P.F., Adams D.J.;
RT   "Globular and ribbon isomers of Conus geographus alpha-conotoxins
RT   antagonize human nicotinic acetylcholine receptors.";
RL   Biochem. Pharmacol. 190:114638-114638(2021).
CC   -!- FUNCTION: Does not show activity on all the human nAChR subtypes
CC       studied. {ECO:0000269|PubMed:34062129}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:34062129}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:34062129}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/8 pattern.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Both the globular (with C1-C3; C2-C4 disulfide pattern)
CC       and ribbon (C1-C4; C2-C3) isomers shows no activity on muscle-type
CC       alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE nAChRs, alpha-3-
CC       beta-2/CHRNA3-CHRNB2, alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-
CC       2/CHRNA4-CHRNB2, alpha-7/CHRNA7, and alpha-9-alpha-10/CHRNA9-CHRNA10.
CC       {ECO:0000269|PubMed:34062129}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   EMBL; AB910810; BAO65578.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..44
FT                   /evidence="ECO:0000305|PubMed:34062129"
FT                   /id="PRO_0000454096"
FT   PEPTIDE         45..68
FT                   /note="Conotoxin G1.9"
FT                   /evidence="ECO:0000305|PubMed:34062129"
FT                   /id="PRO_5004957923"
FT   DISULFID        46..52
FT                   /evidence="ECO:0000305"
FT   DISULFID        47..61
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   68 AA;  7526 MW;  6427D779F6941BED CRC64;
     MGMRMMFTVF LLVVLATTVV SFTSRRGPKS RRGEPVPTTV INYGECCKDP SCWVKVKDFQ
     CPGASPPN