ID   VATG_CAEBR              Reviewed;         126 AA.
AC   Q617N0; A8XKY5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable V-type proton ATPase subunit G;
DE            Short=V-ATPase subunit G;
DE   AltName: Full=Vacuolar proton pump subunit G;
GN   Name=vha-10 {ECO:0000250|UniProtKB:P91303};
GN   ORFNames=CBG14904 {ECO:0000312|WormBase:CBG14904};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase),
CC       a multisubunit enzyme composed of a peripheral complex (V1) that
CC       hydrolyzes ATP and a membrane integral complex (V0) that translocates
CC       protons (By similarity). V-ATPase is responsible for acidifying and
CC       maintaining the pH of intracellular compartments and in some cell
CC       types, is targeted to the plasma membrane, where it is responsible for
CC       acidifying the extracellular environment. In neurons, required for
CC       necrotic cell death by promoting intracellular acidification (By
CC       similarity). {ECO:0000250|UniProtKB:P91303,
CC       ECO:0000250|UniProtKB:Q0VCV6}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme made up of two
CC       complexes: the ATP-hydrolytic V1 complex and the proton translocation
CC       V0 complex. The V1 complex consists of three catalytic AB heterodimers
CC       that form a heterohexamer, three peripheral stalks each consisting of
CC       EG heterodimers, one central rotor including subunits D and F, and the
CC       regulatory subunits C and H. The proton translocation complex V0
CC       consists of the proton transport subunit a, a ring of proteolipid
CC       subunits c9c'', rotary subunit d, subunits e and f, and the accessory
CC       subunits vah-19/Ac45 and vah-20/PRR. {ECO:0000250|UniProtKB:Q0VCV6}.
CC   -!- SIMILARITY: Belongs to the V-ATPase G subunit family. {ECO:0000255}.
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DR   EMBL; HE600904; CAP33309.1; -; Genomic_DNA.
DR   RefSeq; XP_002639086.1; XM_002639040.1.
DR   AlphaFoldDB; Q617N0; -.
DR   SMR; Q617N0; -.
DR   STRING; 6238.CBG14904; -.
DR   EnsemblMetazoa; CBG14904.1; CBG14904.1; WBGene00035279.
DR   GeneID; 8581080; -.
DR   KEGG; cbr:CBG_14904; -.
DR   CTD; 8581080; -.
DR   WormBase; CBG14904; CBP03599; WBGene00035279; Cbr-vha-10.
DR   eggNOG; KOG1772; Eukaryota.
DR   HOGENOM; CLU_125101_1_1_1; -.
DR   InParanoid; Q617N0; -.
DR   OMA; HSKGNEQ; -.
DR   OrthoDB; 1566576at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0012501; P:programmed cell death; ISS:UniProtKB.
DR   InterPro; IPR005124; V-ATPase_G.
DR   PANTHER; PTHR12713; PTHR12713; 1.
DR   Pfam; PF03179; V-ATPase_G; 1.
DR   TIGRFAMs; TIGR01147; V_ATP_synt_G; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport; Ion transport; Reference proteome; Transport.
FT   CHAIN           1..126
FT                   /note="Probable V-type proton ATPase subunit G"
FT                   /id="PRO_0000278128"
FT   REGION          23..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   126 AA;  14586 MW;  12EF7833B804C25C CRC64;
     MASQTQGIQQ LLAAEKRAAE KINEARKRKL QRTKQAKQEA QAEVEKYKQQ REQEFKGFEQ
     QYLGTKEDIE SKIRRDTEDQ INGMKQSVAS NKQAVIVRLL QLVCDIKPEL HHNLTLQKKL
     HGQFAA