ID   VATH_DICDI              Reviewed;         445 AA.
AC   Q8MML6; Q555N2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=V-type proton ATPase subunit H;
DE            Short=V-ATPase subunit H;
DE   AltName: Full=Vacuolar proton pump subunit H;
GN   Name=vatH; ORFNames=DDB_G0274553;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
CC   -!- FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase.
CC       Subunit H activates the ATPase activity of the enzyme and couples
CC       ATPase activity to proton flow. Vacuolar ATPase is responsible for
CC       acidifying a variety of intracellular compartments in eukaryotic cells,
CC       thus providing most of the energy required for transport processes in
CC       the vacuolar system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC       catalytic V1 complex (components A to H) attached to an integral
CC       membrane V0 proton pore complex (components: a, c, c', c'' and d).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the V-ATPase H subunit family. {ECO:0000305}.
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DR   EMBL; AC123513; AAM44365.1; -; Genomic_DNA.
DR   EMBL; AAFI02000012; EAL70169.1; -; Genomic_DNA.
DR   RefSeq; XP_644034.1; XM_638942.1.
DR   AlphaFoldDB; Q8MML6; -.
DR   SMR; Q8MML6; -.
DR   STRING; 44689.DDB0234266; -.
DR   PaxDb; Q8MML6; -.
DR   EnsemblProtists; EAL70169; EAL70169; DDB_G0274553.
DR   GeneID; 8619464; -.
DR   KEGG; ddi:DDB_G0274553; -.
DR   dictyBase; DDB_G0274553; vatH.
DR   eggNOG; KOG2759; Eukaryota.
DR   HOGENOM; CLU_025709_4_0_1; -.
DR   InParanoid; Q8MML6; -.
DR   OMA; KDQNVRY; -.
DR   PhylomeDB; Q8MML6; -.
DR   Reactome; R-DDI-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-DDI-77387; Insulin receptor recycling.
DR   Reactome; R-DDI-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q8MML6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031164; C:contractile vacuolar membrane; TAS:dictyBase.
DR   GO; GO:0140220; C:pathogen-containing vacuole; HDA:dictyBase.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.40.150; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR004908; ATPase_V1-cplx_hsu.
DR   InterPro; IPR011987; ATPase_V1-cplx_hsu_C.
DR   InterPro; IPR038497; ATPase_V1-cplx_hsu_C_sf.
DR   PANTHER; PTHR10698; PTHR10698; 1.
DR   Pfam; PF11698; V-ATPase_H_C; 1.
DR   Pfam; PF03224; V-ATPase_H_N; 1.
DR   PIRSF; PIRSF032184; ATPase_V1_H; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   1: Evidence at protein level;
KW   Hydrogen ion transport; Ion transport; Reference proteome; Transport.
FT   CHAIN           1..445
FT                   /note="V-type proton ATPase subunit H"
FT                   /id="PRO_0000328461"
SQ   SEQUENCE   445 AA;  50790 MW;  8AD914D00FB9720B CRC64;
     MNFRELDTSN GVKAAESSFR TKVVLAREIP WNGFASSNSI TSEQYNLISK YDKHTDAEKK
     EKFAANSASY VNFFVNFINS TSNIEIIQYL LTLINEIIEI DPRAAGAFSK ITKDDDKSYP
     YSVFFRLLNR EDAYTNLHAS IALAQIMCAG KPTQNDVESF FNWILKLLRK NNSSEVEVGL
     IALQSLLLKD DFRIFFNNID GSALLLNILQ ALSTSSVNIQ LLYETIYAIW LLTYNKDIAA
     AYSGTGLVAN LVQLVKTVAK EKIVRLSLST LRNLLNNGKS NEEMIDNGFV RMLNILNIKK
     WGDDDIPADI EVLINGLAKD IDNMSSFNKY KTEIISGELE WTPVHKSERF WKENISKFEE
     NNYQVIKHLH QILKTSQSTP LQLSIACHDL CEFVRHHSRG KAIMTITNQT RYHGYDVKSN
     EEVKNQALFA LQKMMLNNWE YLNAK