VATH_SCHPO
ID VATH_SCHPO Reviewed; 450 AA.
AC O14265;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 2.
DT 25-MAY-2022, entry version 148.
DE RecName: Full=V-type proton ATPase subunit H;
DE Short=V-ATPase subunit H;
DE AltName: Full=V-ATPase 54 kDa subunit;
DE AltName: Full=Vacuolar proton pump subunit H;
GN Name=vma13; ORFNames=SPAC7D4.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase),
CC a multisubunit enzyme composed of a peripheral complex (V1) that
CC hydrolyzes ATP and a membrane integral complex (V0) that translocates
CC protons (By similarity). V-ATPase is responsible for acidifying and
CC maintaining the pH of intracellular compartments (By similarity). This
CC subunit is essential for activity, but not assembly, of the enzyme
CC complex (By similarity). This subunit is also required for silencing
CC the ATPase activity of V-ATPase when V1 is detached from V0 (By
CC similarity). {ECO:0000250|UniProtKB:P41807}.
CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC catalytic V1 complex (components A to H) attached to an integral
CC membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and
CC VOA1). {ECO:0000250|UniProtKB:P41807}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P41807};
CC Peripheral membrane protein {ECO:0000305}; Cytoplasmic side
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the V-ATPase H subunit family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16727.2; -; Genomic_DNA.
DR PIR; T39088; T39088.
DR RefSeq; NP_593848.1; NM_001019277.2.
DR AlphaFoldDB; O14265; -.
DR SMR; O14265; -.
DR STRING; 4896.SPAC7D4.10.1; -.
DR MaxQB; O14265; -.
DR PaxDb; O14265; -.
DR EnsemblFungi; SPAC7D4.10.1; SPAC7D4.10.1:pep; SPAC7D4.10.
DR GeneID; 2541906; -.
DR KEGG; spo:SPAC7D4.10; -.
DR PomBase; SPAC7D4.10; vma13.
DR VEuPathDB; FungiDB:SPAC7D4.10; -.
DR eggNOG; KOG2759; Eukaryota.
DR HOGENOM; CLU_025709_4_0_1; -.
DR InParanoid; O14265; -.
DR OMA; KDQNVRY; -.
DR PhylomeDB; O14265; -.
DR Reactome; R-SPO-1222556; ROS and RNS production in phagocytes.
DR Reactome; R-SPO-77387; Insulin receptor recycling.
DR Reactome; R-SPO-917977; Transferrin endocytosis and recycling.
DR Reactome; R-SPO-9639288; Amino acids regulate mTORC1.
DR PRO; PR:O14265; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; ISO:PomBase.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IC:PomBase.
DR GO; GO:0007035; P:vacuolar acidification; ISO:PomBase.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 1.25.40.150; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004908; ATPase_V1-cplx_hsu.
DR InterPro; IPR011987; ATPase_V1-cplx_hsu_C.
DR InterPro; IPR038497; ATPase_V1-cplx_hsu_C_sf.
DR PANTHER; PTHR10698; PTHR10698; 1.
DR Pfam; PF11698; V-ATPase_H_C; 1.
DR Pfam; PF03224; V-ATPase_H_N; 1.
DR PIRSF; PIRSF032184; ATPase_V1_H; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Hydrogen ion transport; Ion transport; Membrane; Reference proteome;
KW Transport; Vacuole.
FT CHAIN 1..450
FT /note="V-type proton ATPase subunit H"
FT /id="PRO_0000124201"
SQ SEQUENCE 450 AA; 51437 MW; 8BBA5D0BD56528A4 CRC64;
MSNSDLELSN AASPPPVELD NSQVDEIINN VRCVAIPWQG YQRSGSLEEN ELQEIENLTG
KPLSAYVKTA EEDTTAYSNL FLKLLSMKDT PDVVNFALVK LADTLLNSNK FLSAFGPAFY
DFLEKDESYI NYLDDDSKLL FARVFALCSS SSPCSVAKAF TLFLEYLGKL MQSLNPLTRL
FAVQCLNGVL TLKAHRYALW AENTCSFRLA ELLRNSIGDT QLQYYSLFCF WQLTFESHIA
QDINKRFDLI KLLVQIIRSD TKTKVYRLVL AILVNLIDKA PKDTISTMLL EHVDKAVQLL
QKRKWADEDI TNYLDFITST LDESSKHLST FDMYKSELDT GILHWSPSHR SEDFWHQNAK
RLNEDNYALL KKLFHIVQYN EDNTSLAVAC HDLGAYIRSY PEGRSLIIKY GAKQRIMDLM
SHPDPEVRFE ALSTVQLLMT EVCFLSKITL
