ID   VATI_HALSA              Reviewed;         722 AA.
AC   Q9HND8;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2001, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=V-type ATP synthase subunit I;
DE   AltName: Full=V-ATPase subunit I;
GN   Name=atpI; OrderedLocusNames=VNG_2144G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AE004437; AAG20282.1; -; Genomic_DNA.
DR   PIR; F84364; F84364.
DR   RefSeq; WP_010903584.1; NC_002607.1.
DR   AlphaFoldDB; Q9HND8; -.
DR   SMR; Q9HND8; -.
DR   STRING; 64091.VNG_2144G; -.
DR   PaxDb; Q9HND8; -.
DR   EnsemblBacteria; AAG20282; AAG20282; VNG_2144G.
DR   GeneID; 5953579; -.
DR   KEGG; hal:VNG_2144G; -.
DR   PATRIC; fig|64091.14.peg.1642; -.
DR   HOGENOM; CLU_025558_2_1_2; -.
DR   InParanoid; Q9HND8; -.
DR   OMA; MLRPERM; -.
DR   OrthoDB; 14889at2157; -.
DR   PhylomeDB; Q9HND8; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..722
FT                   /note="V-type ATP synthase subunit I"
FT                   /id="PRO_0000119228"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        554..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        590..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        639..659
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        662..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          309..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..323
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   722 AA;  77176 MW;  3F70DAD3F4389EB2 CRC64;
     MLRPEQMSKV SVAGSTHVLT PVIEAVHDAE LVHLSDYDGG IDGFDNGDPM TGADEAAEKL
     VTVRSLKSLL DVSEGDAGPT RIVTDDALDT ELESIRVEAT DLDDRRSELT DDLRAVIERI
     DAAEPFADLG IDLDLLSGYD SLQVAVGTGD QSAIDAALAA SDRISAFETF TGQDTIGVFA
     YPAADDDAAL DDALVGVPFT RLDVPDADGS PEQYVSELRE RRDTIQAEIE DVDDELAAFR
     DEHAGFLLAA EERLAIDVQK SEAPLQFAST SHAFVAEGWL PTSEYDAFTD AIESAVGDHV
     LVEELERADY KPTGHDQHVP ADDGADAATD GGTTASFDET DSPPVIQDNP GPVSSFESLT
     EVINRPQYTE IDPTVVLFLT FPAFYGFMIG DLGYGVLYAL LGFWLSRSFD SEMISKLGGV
     AMWAGGFTAL FGVLYGEVFG LHLVTEYLWH GALGLADAPL KKGLHVSAFA ELWLAASLVF
     GIAHLAIGYV FGFVNESRSH GLKDAALESG GQLLLMAGVG VWLFSTHMQS GGGPRPELLY
     SVVALPPIVG KAGLAAAVVG LVLVTLGEGA AGFLESPTYA LVNTVSYTRI AAVLLAKAGM
     AYVVNLLVFG AYETHLEHPE TIDYMFGLFS TTIEHETHFM LFSGEAHGEV LFPGLMHMGA
     AGILIGVLVL LVGHALVLAL GVTSAGLQAL RLEYVEFFNK FYEGGGEKYN PFGYTRNYTT
     ED