ID   VATI_METTH              Reviewed;         658 AA.
AC   O27041;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=V-type ATP synthase subunit I;
DE   AltName: Full=V-ATPase subunit I;
GN   Name=atpI; OrderedLocusNames=MTH_960;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AE000666; AAB85456.1; -; Genomic_DNA.
DR   PIR; E69228; E69228.
DR   AlphaFoldDB; O27041; -.
DR   SMR; O27041; -.
DR   IntAct; O27041; 2.
DR   STRING; 187420.MTH_960; -.
DR   EnsemblBacteria; AAB85456; AAB85456; MTH_960.
DR   KEGG; mth:MTH_960; -.
DR   PATRIC; fig|187420.15.peg.943; -.
DR   HOGENOM; CLU_025558_1_0_2; -.
DR   OMA; MAVNIMA; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..658
FT                   /note="V-type ATP synthase subunit I"
FT                   /id="PRO_0000119231"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        507..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        530..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        568..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   658 AA;  74476 MW;  98E48D62EB43BE81 CRC64;
     MSDMFLPARM RKLKIITLDQ YSDSVVRSLH EEGVTQIDDI SERIQQDAEW RQILKPSRAT
     PYTGRVSSLL MKTSGILDFL GSVAAEEKGL RDTIREFINP PIFEKREVEE LDTESLIERA
     EETLGRVESE TRVMEEKLNE LDSERSAVES SLSVAEKLKD FDIDFSDLQD SEYITGIAGR
     ITAENLPELR DKLADITDEL VISDREGENK AERILIIVTL KKHADSIASV LRRMEFERFE
     ISELQGRPSE IISSSKTRLE EISRERKEII SKLRDINAEW EDELLVLREQ LEIEKERNEV
     FSLFGETRKT VMLEAWVPLK EADRVIAVVE ESSEGTALTD LEDPDPEEVP VLLDNPRFAK
     PYETFVEMYS PLKYNEIDPT IFMAFVFPFF FGFCLTDAGY GIIDALIGFI LYRGLGKVNN
     FMRNFGIIMM SCGVWAFILG MVTNGFIGDF FPRFFNITLP TVIPAIDAFV NPQNILIMAL
     TVGVLHINFG LILGARNNIR LGNMREALGS QIVWLILELG IILYLVGGMI FGAPLIILAF
     AMLLYYNGLF GLMDVSGFLG TLLSYARLLA LCLSTGGIAM TVNILTGLSY EMIPVIGVVL
     APIIFVFGHI ANNAFQSLGA FINSLRLHYV EFFAQFYMGG KNKFNAFRAE RNFTKIRR