ID   VATI_PYRHO              Reviewed;         659 AA.
AC   O57721;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=V-type ATP synthase subunit I;
DE   AltName: Full=V-ATPase subunit I;
GN   Name=atpI; OrderedLocusNames=PH1981;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BA000001; BAA31108.1; -; Genomic_DNA.
DR   PIR; E71214; E71214.
DR   RefSeq; WP_010886044.1; NC_000961.1.
DR   AlphaFoldDB; O57721; -.
DR   SMR; O57721; -.
DR   STRING; 70601.3258425; -.
DR   PRIDE; O57721; -.
DR   EnsemblBacteria; BAA31108; BAA31108; BAA31108.
DR   GeneID; 1442826; -.
DR   KEGG; pho:PH1981; -.
DR   eggNOG; arCOG04138; Archaea.
DR   OMA; MAVNIMA; -.
DR   OrthoDB; 14889at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..659
FT                   /note="V-type ATP synthase subunit I"
FT                   /id="PRO_0000119233"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        542..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        568..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        590..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   659 AA;  74308 MW;  EE4B1AEEB97FCA33 CRC64;
     MFKPEKIVKI EVITLTRFRD TLLTYLHEIG VAQLEEVPIK EVQRDTPNEF YRKATSYSIT
     LSRLVDTLKQ YLPPKKGGFK EFMFPQEKPK KKYKYKGIEA LIKDVETFLE RVEPEIRSLE
     SEVSRINNEI SSLEDTLESL QILSNLNVEV EYLRGGSFLN VDVGLVDREK AEPLIKEISD
     VVEGRVHIVR KDIGARTLLV VVSLREDSSK VSSVLAKYGF EKIEVPEGKG LPRDLIPIYT
     EKIKEKEKEL EEVKSRGRKV AERYYDELVF YKELMDNERE KGNYLSYLVR TEMTFGLLAW
     VPEKDVEKVV EGIKKITGGV AYINISEPSK EEIDNVPVKL KNPEFLSHFE MLTEMYGVPK
     YNEIDPTPIM AFTYSFFFGF MLTDFVYGLL LGIISALLVK GHSKLKDGTW KFAKIMLWSS
     VFTMTLGILF GSYCGNALDM AGIKVPRILD PMEQALTVLM IALAIGLAHL FTGYLLGFIV
     RWKNGDKKGA IFEQLSWLLI IIGITLFALS SRLGVPDLIV KGIFGIGLIL FMIGEVLANK
     GMAVLLVISD FFGFVGNWLS YARLMALALA TSGIALVINI LVEMIWGIKI ASVPLGALIG
     ILVLIGGHIF STAINALGAF VHALRLHYVE FFGTFYSGEG RKFEPFAAKR EVSELEIET