ID   VATI_SACS2              Reviewed;         701 AA.
AC   Q9UWW3;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=V-type ATP synthase subunit I;
DE   AltName: Full=V-ATPase subunit I;
GN   Name=atpI; OrderedLocusNames=SSO0559; ORFNames=C21_040;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=10701121; DOI=10.1139/g99-108;
RA   Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C.,
RA   Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T.,
RA   Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E.,
RA   Medina N., Peng X., Penny S.L., She Q., St Jean A., van der Oost J.,
RA   Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W.;
RT   "Gene content and organization of a 281-kbp contig from the genome of the
RT   extremely thermophilic archaeon, Sulfolobus solfataricus P2.";
RL   Genome 43:116-136(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; Y18930; CAB57740.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK40876.1; -; Genomic_DNA.
DR   PIR; E90202; E90202.
DR   AlphaFoldDB; Q9UWW3; -.
DR   SMR; Q9UWW3; -.
DR   STRING; 273057.SSO0559; -.
DR   PRIDE; Q9UWW3; -.
DR   EnsemblBacteria; AAK40876; AAK40876; SSO0559.
DR   KEGG; sso:SSO0559; -.
DR   PATRIC; fig|273057.12.peg.569; -.
DR   eggNOG; arCOG04138; Archaea.
DR   HOGENOM; CLU_025558_0_0_2; -.
DR   InParanoid; Q9UWW3; -.
DR   OMA; MAVNIMA; -.
DR   PhylomeDB; Q9UWW3; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..701
FT                   /note="V-type ATP synthase subunit I"
FT                   /id="PRO_0000119235"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        498..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        583..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        612..632
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        649..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   701 AA;  80132 MW;  FBC53187B01B31EA CRC64;
     MLLPENMVRL QIISDKSAID PIITKLLKLG MFQPEDPLYP LGNERIEDAR RLITAVQDHV
     SKLKIIMELG GLVIEPLGSI KVSSWIKAAQ DVSEEASKLE ERYKELLEEI GRLRSEKDLY
     QQQLKELEPI KSITVELSKL YSLELFDVIL AQVDEDKLRL INQIIGDSNF VYYTRFGEER
     YIVLIIAEKN INVDKKLREA GVRRYELQEG KSPFQLYNEI LERINQINII LERTREELAK
     KVKTEENYIK NVYGKLLTVR DALNIMNKAR VSEYYLQIEG YFPEKHVKKV QNEINNLAFM
     DYIRPRRYGE KEEPPTLVEL PKSIKVLESL VEIYGSPSYW EISPIVFLVF TFPILFGLMF
     PDFGNALVLL LFSIWFYRYG KKRGSENIPK LSIILIYSSI VAIITGLLAR DFFGPLPVGG
     LREILNNGNY SAGPLYNLWP IPASVSEAIK FLLPFGEYST SVSIENTMIF SVLLGALALF
     VSSLLGVIDA IRKKDPEFLF LEKLPLFLLY VVPIFIFMYG ITDPANFFTV DQQILGQILN
     AVLMKSFSEN IVGYGIVWWT SFALLYNWAA HAILVKRHDN ATWGSAIAMG FIEGGFEGAL
     LLLSNTISFI RVLVFALSHY YILYAFSYMA YLVAPSTTTI GVLINPIAII ILIIGNLLAI
     GLEGLVVFIQ DLRLHFYEMF SKFYEGRGRK FEPVMAYVSL E