ID   VATI_THEKO              Reviewed;         663 AA.
AC   Q5JDS2;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=V-type ATP synthase subunit I;
DE   AltName: Full=V-ATPase subunit I;
GN   Name=atpI; OrderedLocusNames=TK1597;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC       across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AP006878; BAD85786.1; -; Genomic_DNA.
DR   RefSeq; WP_011250548.1; NC_006624.1.
DR   AlphaFoldDB; Q5JDS2; -.
DR   SMR; Q5JDS2; -.
DR   STRING; 69014.TK1597; -.
DR   EnsemblBacteria; BAD85786; BAD85786; TK1597.
DR   GeneID; 3235547; -.
DR   KEGG; tko:TK1597; -.
DR   PATRIC; fig|69014.16.peg.1556; -.
DR   eggNOG; arCOG04138; Archaea.
DR   HOGENOM; CLU_025558_1_0_2; -.
DR   InParanoid; Q5JDS2; -.
DR   OMA; MAVNIMA; -.
DR   OrthoDB; 14889at2157; -.
DR   PhylomeDB; Q5JDS2; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..663
FT                   /note="V-type ATP synthase subunit I"
FT                   /id="PRO_0000119234"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        497..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        534..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        568..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        589..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   663 AA;  74829 MW;  810002BA97D94538 CRC64;
     MFRPEEMVKL EVITLNRYKD TLLTYLHEAG AVEVREVKVE LAQKDTPNEY HRKAASYSIS
     MSRLVEFLGT YRKAAGGGIK EFFFPKEKPK RTYRYERLEK LIKDVEEFLG KVEPEIKAIE
     GRMNSLSTEI ERIKEQIGIL DILTPLNIDV SYLRHCGVVE VTVGLVDRTR VKELADALKK
     ETENHVAIIT KEASDKALVV IVNLARDHDK VNTLLAKFSV EKLEIPEGEG TPKELMKEYS
     KKLAEKEKEL EEAKKEASKL AEKYYDDVLF YKELVDNERD KSTVLPMLAR TNMTFALTGW
     VPRPDVQKIL EGIKRITEGK AYINVREPRK EELEEMPVKL KNPGWARPFE MLTEMYGVPR
     HDEIDPTPII AFTYSFFFGF MLTDFLYGLI VGIVAALLVK GHKKFNDGTY KFAYILLWSA
     FFTMLLGALF GSYFGNAADI MLQYITGDQN AHAWRLLDPL REPMPMLLAA LAIGLAHLFL
     GYTLGFVIKW KNGDRKGAVF EQLPWMIIII GVALLASQRE GLDAAAKAIL GTGIALFAVG
     ELVINGGLAA LMIISDFFGF VGNWLSYARL MALALATGGI AMVINVLVGM VWAIKFLYIG
     PIIGLIIFFG GQLFSTAINA LGAFVHALRL HYVEFFGTFY SGEGKRFEPF KSKREVSKLE
     LEV