VATL5_ARATH
ID VATL5_ARATH Reviewed; 164 AA.
AC P0DH94; P59227; Q39037; Q39038; Q39039; Q42424; Q6IDA4; Q96298;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=V-type proton ATPase subunit c5;
DE Short=V-ATPase subunit c5;
DE AltName: Full=V-type proton ATPase 16 kDa proteolipid subunit c5;
DE Short=V-ATPase 16 kDa proteolipid subunit c5;
DE AltName: Full=Vacuolar H(+)-ATPase subunit c isoform 5;
DE AltName: Full=Vacuolar proton pump 16 kDa proteolipid subunit c5;
DE AltName: Full=Vacuolar proton pump subunit c5;
GN Name=VHA-c5; Synonyms=AVA-P5, AVAP5; OrderedLocusNames=At2g16510;
GN ORFNames=F1P15.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11950611; DOI=10.1016/s1360-1385(02)02240-9;
RA Sze H., Schumacher K., Mueller M.L., Padmanaban S., Taiz L.;
RT "A simple nomenclature for a complex proton pump: VHA genes encode the
RT vacuolar H(+)-ATPase.";
RL Trends Plant Sci. 7:157-161(2002).
CC -!- FUNCTION: Proton-conducting pore forming subunit of the membrane
CC integral V0 complex of vacuolar ATPase. V-ATPase is responsible for
CC acidifying a variety of intracellular compartments in eukaryotic cells.
CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC catalytic V1 complex (components A to H) attached to an integral
CC membrane V0 proton pore complex (components: a, c, c'', d and e). The
CC proteolipid components c and c'' are present as a hexameric ring that
CC forms the proton-conducting pore.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.
CC Note=Tonoplast.
CC -!- SIMILARITY: Belongs to the V-ATPase proteolipid subunit family.
CC {ECO:0000305}.
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DR EMBL; AC007195; AAD26493.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06505.1; -; Genomic_DNA.
DR EMBL; BT014769; AAT41752.1; -; mRNA.
DR EMBL; BT015005; AAT70456.1; -; mRNA.
DR PIR; S60130; S60130.
DR RefSeq; NP_179244.1; NM_127205.5.
DR RefSeq; NP_195198.1; NM_119638.3.
DR RefSeq; NP_195603.1; NM_120052.3.
DR AlphaFoldDB; P0DH94; -.
DR SMR; P0DH94; -.
DR BioGRID; 14906; 2.
DR BioGRID; 15327; 4.
DR EnsemblPlants; AT2G16510.1; AT2G16510.1; AT2G16510.
DR EnsemblPlants; AT4G34720.1; AT4G34720.1; AT4G34720.
DR EnsemblPlants; AT4G38920.1; AT4G38920.1; AT4G38920.
DR GeneID; 816150; -.
DR GeneID; 829624; -.
DR GeneID; 830047; -.
DR Gramene; AT2G16510.1; AT2G16510.1; AT2G16510.
DR Gramene; AT4G34720.1; AT4G34720.1; AT4G34720.
DR Gramene; AT4G38920.1; AT4G38920.1; AT4G38920.
DR KEGG; ath:AT2G16510; -.
DR KEGG; ath:AT4G34720; -.
DR KEGG; ath:AT4G38920; -.
DR Araport; AT2G16510; -.
DR TAIR; locus:2045101; AT2G16510.
DR HOGENOM; CLU_085752_1_0_1; -.
DR InParanoid; P0DH94; -.
DR OMA; MSVCPPY; -.
DR OrthoDB; 1534092at2759; -.
DR PhylomeDB; P0DH94; -.
DR PRO; PR:P0DH94; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P0DH94; baseline and differential.
DR Genevisible; P0DH94; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; HDA:TAIR.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR Gene3D; 1.20.120.610; -; 1.
DR InterPro; IPR002379; ATPase_proteolipid_c-like_dom.
DR InterPro; IPR000245; ATPase_proteolipid_csu.
DR InterPro; IPR011555; ATPase_proteolipid_su_C_euk.
DR InterPro; IPR035921; F/V-ATP_Csub_sf.
DR Pfam; PF00137; ATP-synt_C; 2.
DR PRINTS; PR00122; VACATPASE.
DR SUPFAM; SSF81333; SSF81333; 2.
DR TIGRFAMs; TIGR01100; V_ATP_synt_C; 1.
PE 2: Evidence at transcript level;
KW Hydrogen ion transport; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..164
FT /note="V-type proton ATPase subunit c5"
FT /id="PRO_0000415776"
FT TOPO_DOM 1..11
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..94
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..164
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT SITE 141
FT /note="Essential for proton translocation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 164 AA; 16572 MW; 7015A76D759D5EF9 CRC64;
MSTFSGDETA PFFGFLGAAA ALVFSCMGAA YGTAKSGVGV ASMGVMRPEL VMKSIVPVVM
AGVLGIYGLI IAVIISTGIN PKAKSYYLFD GYAHLSSGLA CGLAGLSAGM AIGIVGDAGV
RANAQQPKLF VGMILILIFA EALALYGLIV GIILSSRAGQ SRAE
