ID   VAX1A_XENLA             Reviewed;         295 AA.
AC   O93528;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Ventral anterior homeobox 1a;
GN   Name=vax1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Head;
RX   PubMed=9636075; DOI=10.1242/dev.125.14.2599;
RA   Hallonet M., Hollemann T., Wehr R., Jenkins N.A., Copeland N.G., Pieler T.,
RA   Gruss P.;
RT   "Vax1 is a novel homeobox-containing gene expressed in the developing
RT   anterior ventral forebrain.";
RL   Development 125:2599-2610(1998).
CC   -!- FUNCTION: May play a role in the specification and maintenance of basal
CC       forebrain identity. {ECO:0000269|PubMed:9636075}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: First detectable at early gastrula stages.
CC       Expressed in the anterior-most region of the open neural plate and
CC       midanterior and midlateral anterior ridge. By late neurula stages,
CC       expressed in the derivatives of these regions namely, in the anterior
CC       and rostral ventrolateral part of the forebrain neuroepithelium,
CC       primordium striatum, optic stalk, chiasmatic ridge and the anterior
CC       hypothalamus. At tailbud stages the expression extends laterally and
CC       caudally with the enlargement of the forebrain ventricle. Expression in
CC       the tadpole stage embryos is specific to the optic disk, optic stalk
CC       and anterior hypothalamus. {ECO:0000269|PubMed:9636075}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR   EMBL; AF064601; AAC35794.1; -; mRNA.
DR   RefSeq; NP_001079149.1; NM_001085680.1.
DR   AlphaFoldDB; O93528; -.
DR   SMR; O93528; -.
DR   GeneID; 373698; -.
DR   KEGG; xla:373698; -.
DR   CTD; 373698; -.
DR   Xenbase; XB-GENE-6252856; vax1.S.
DR   OrthoDB; 1094882at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 373698; Expressed in brain and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR033020; Vax1.
DR   PANTHER; PTHR24339:SF32; PTHR24339:SF32; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..295
FT                   /note="Ventral anterior homeobox 1a"
FT                   /id="PRO_0000240527"
FT   DNA_BIND        97..156
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          20..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  32828 MW;  ACAF83506AD6727F CRC64;
     MFEKTTDMDI RCNIEENGRI SKPKDNKEIR ETQAKMPSTY LKEQPGTYPA PGSSELCAKN
     KSSSAGDPEY CRRILVRDAK GSIREIILPK GLDLDRPKRS RTSFTAEQLY RLEMEFQRCQ
     YVVGRERTDL SRQLNLSETQ VKVWFQNRRT KQKKDQGKDS ELRSVVSETA ATCSVLRLLE
     QGRLLSPPGL PGLMPPCTTG TLRAPNSSGP GTRSLATVTS TPPHQPGLHP SPTGHNIFNM
     PVPSLLGTVA NRLSSHPLTM AGNLHELSAR YLSSSAFEPY SRSISKDSLD KKLLD