ID   VAX1B_XENLA             Reviewed;         287 AA.
AC   Q9DDB0;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Ventral anterior homeobox 1b;
GN   Name=vax1-b; Synonyms=vax1b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11118895; DOI=10.1016/s0925-4773(00)00505-0;
RA   Liu Y., Lupo G., Marchitiello A., Gestri G., He R.-Q., Banfi S.,
RA   Barsacchi G.;
RT   "Expression of the Xvax2 gene demarcates presumptive ventral telencephalon
RT   and specific visual structures in Xenopus laevis.";
RL   Mech. Dev. 100:115-118(2001).
CC   -!- FUNCTION: Involved in ventral eye development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: At early neurula stages, exclusively activated in
CC       the presumptive ventral telencephalon. Since midneurula stages also
CC       found in the medial aspect of the eye field. At tailbud and tadpole
CC       stages, expression seen in the optic stalk, optic nerve, optic disk,
CC       ventral retina, ventral telencephalon and diencephalon. Finally during
CC       metamorphosis expression is maintained in the optic chiasm, ventral
CC       hypothalamus and hypophysis. {ECO:0000269|PubMed:11118895}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ271730; CAC19632.1; -; mRNA.
DR   RefSeq; NP_001079317.1; NM_001085848.1.
DR   AlphaFoldDB; Q9DDB0; -.
DR   SMR; Q9DDB0; -.
DR   GeneID; 378629; -.
DR   KEGG; xla:378629; -.
DR   CTD; 378629; -.
DR   Xenbase; XB-GENE-1188142; vax1.L.
DR   OrthoDB; 1094882at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 378629; Expressed in neurula embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR033020; Vax1.
DR   PANTHER; PTHR24339:SF32; PTHR24339:SF32; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..287
FT                   /note="Ventral anterior homeobox 1b"
FT                   /id="PRO_0000240528"
FT   DNA_BIND        89..148
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   287 AA;  31981 MW;  A39AD23399688DB9 CRC64;
     MFEKTRDMDV RCNIEENGRI SKPKDNKEIR ESQSKMPSTY PAPGSSEGCA KNKSSSAVDP
     EYCRRILVRD AKGSLREIIL PKGLDLDRPK RTRTSFTAEQ LYRLEMEFQR CQYVVGRERT
     ELARQLNLSE TQVKVWFQNR RTKQKKDQGK DSELRSVVSE TAATCSVLRL LEQGRLLSPP
     GLPGLMPPCT TGTLRAPNSS GPGTTSLPTV TNTHPHQPGL HPSPTGHNIF NMPVPSLLGT
     VANRLSSHPL TMAGNLQELS ARYLSSSAFE PYSRSISKDS LDKKLLD