ID   VAX1_CHICK              Reviewed;         327 AA.
AC   Q9PVN2; Q9PTR3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Ventral anterior homeobox 1;
GN   Name=VAX1; Synonyms=VAX;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Retina;
RX   PubMed=10595508; DOI=10.1016/s0896-6273(00)81111-3;
RA   Schulte D., Furukawa T., Peters M.A., Kozak C.A., Cepko C.L.;
RT   "Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes
RT   the retina and perturbs the retinotectal map.";
RL   Neuron 24:541-553(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kanae O., Takahashi N.;
RT   "Chick Vax homeobox gene.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that plays a role in establishing
CC       dorsal-ventral polarity in the neural retina.
CC       {ECO:0000269|PubMed:10595508}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: First detected within the ventral eye at
CC       Hamburger-Hamilton (HH) stage 14 as the optic vesicle invaginates.
CC       Expression restricted to the ventral retina at HH stage 22 and at E4 as
CC       well as later in development. {ECO:0000269|PubMed:10595508}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF20017.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF117299; AAF20017.1; ALT_FRAME; mRNA.
DR   EMBL; AB032248; BAA84282.1; -; mRNA.
DR   RefSeq; NP_990130.2; NM_204799.2.
DR   AlphaFoldDB; Q9PVN2; -.
DR   SMR; Q9PVN2; -.
DR   STRING; 9031.ENSGALP00000015056; -.
DR   PaxDb; Q9PVN2; -.
DR   GeneID; 395582; -.
DR   KEGG; gga:395582; -.
DR   CTD; 11023; -.
DR   VEuPathDB; HostDB:geneid_395582; -.
DR   eggNOG; KOG0843; Eukaryota.
DR   HOGENOM; CLU_071850_0_0_1; -.
DR   InParanoid; Q9PVN2; -.
DR   OrthoDB; 1094882at2759; -.
DR   PhylomeDB; Q9PVN2; -.
DR   PRO; PR:Q9PVN2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR033020; Vax1.
DR   PANTHER; PTHR24339:SF32; PTHR24339:SF32; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..327
FT                   /note="Ventral anterior homeobox 1"
FT                   /id="PRO_0000240525"
FT   DNA_BIND        99..158
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        203
FT                   /note="A -> T (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        229..230
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        256
FT                   /note="A -> T (in Ref. 1; AAF20017)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   327 AA;  34141 MW;  F7D7016E736365A1 CRC64;
     MFGKQDKMDV RCSTETEANR VSKNGHKEGK DSKGAEGNIS TSFLKEQQGT FSASAATEDC
     NKSKSGSADP DYCRRILVRD AKGSIREIIL PKGLDLDRPK RTRTSFTAEQ LYRLEMEFQR
     CQYVVGRERT ELARQLNLSE TQVKVWFQNR RTKQKKDQGK DSELRSVVSE TAATCSVLRL
     LEQGRLLSPP GLPGLLPPCA SGALGSALRG PGLAAGSGTA AAAAAAAAAA PAGGSPHPPS
     AGTAAGPPPP AALHGAAAAA AGHGLFGLPV PTLLGSVAGR LSSAPLAVAG SLAGNLQELS
     ARYLSSSAFE PYSRTNNKES AEKKALD